Biomaterials containing extracellular matrix molecules as biomimetic next-generation vascular grafts

Shouyuan Jiang; Steven G Wise; Jason C Kovacic; Jelena Rnjak-Kovacina; Megan S Lord

doi:10.1016/j.tibtech.2023.09.009

Biomaterials containing extracellular matrix molecules as biomimetic next-generation vascular grafts

Trends Biotechnol. 2024 Mar;42(3):369-381. doi: 10.1016/j.tibtech.2023.09.009. Epub 2023 Oct 16.

Authors

Shouyuan Jiang¹, Steven G Wise², Jason C Kovacic³, Jelena Rnjak-Kovacina¹, Megan S Lord⁴

Affiliations

¹ Graduate School of Biomedical Engineering, University of New South Wales, Sydney, NSW 2052, Australia.
² School of Medical Sciences, Faculty of Health and Medicine, University of Sydney, Sydney, NSW 2006, Australia; Charles Perkins Centre, University of Sydney, Sydney, NSW 2006, Australia; The University of Sydney Nano Institute, University of Sydney, Sydney, NSW 2006, Australia.
³ Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia; St Vincent's Clinical School, University of New South Wales, Darlinghurst, NSW 2010, Australia; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
⁴ Graduate School of Biomedical Engineering, University of New South Wales, Sydney, NSW 2052, Australia. Electronic address: m.lord@unsw.edu.au.

PMID: 37852854
DOI: 10.1016/j.tibtech.2023.09.009

Abstract

The performance of synthetic biomaterial vascular grafts for the bypass of stenotic and dysfunctional blood vessels remains an intractable challenge in small-diameter applications. The functionalization of biomaterials with extracellular matrix (ECM) molecules is a promising approach because these molecules can regulate multiple biological processes in vascular tissues. In this review, we critically examine emerging approaches to ECM-containing vascular graft biomaterials and explore opportunities for future research and development toward clinical use.

Keywords: biomaterial; blood vessel; extracellular matrix; vascular graft.

Publication types

Review

MeSH terms

Biocompatible Materials*
Biomimetics*
Blood Vessel Prosthesis
Extracellular Matrix
Tissue Engineering

Substances

Biocompatible Materials