Alternaphenol B2, a new IDH1 inhibitor from the coral-derived fungus Parengyodontium album SCSIO SX7W11

Xiaoyue Li; Wenbin Shen; Guochao Li; Yongxiang Song; Xinhua Lu; Nai-Kei Wong; Yan Yan

doi:10.1080/14786419.2023.2269462

Alternaphenol B2, a new IDH1 inhibitor from the coral-derived fungus Parengyodontium album SCSIO SX7W11

Nat Prod Res. 2023 Oct 18:1-7. doi: 10.1080/14786419.2023.2269462. Online ahead of print.

Authors

Xiaoyue Li^{1

2}, Wenbin Shen³, Guochao Li³, Yongxiang Song^{1

2}, Xinhua Lu³, Nai-Kei Wong⁴, Yan Yan^{1

2}

Affiliations

¹ CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangzhou, China.
² College of Oceanology, University of Chinese Academy of Sciences, Qingdao, China.
³ New Drug Research and Development Center of North China Pharmaceutical Group Corporation, National Microbial Medicine Engineering and Research Center, Hebei Industry Microbial Metabolic Engineering and Technology Research Center, Key Laboratory for New Drug Screening Technology of Shijiazhuang City, Shijiazhuang, Hebei, China.
⁴ Clinical Pharmacology Section, Department of Pharmacology, Shantou University Medical College, Shantou, China.

PMID: 37850447
DOI: 10.1080/14786419.2023.2269462

Abstract

A new aromatic polyketide, alternaphenol B2 (1), and four known compounds (2-5) were isolated from the coral-derived fungus Parengyodontium album SCSIO SX7W11. Their structures were elucidated by high-resolution mass spectrometry, 1D and 2D NMR spectroscopy and comparison with reported literatures. Compounds 1 and 2 exhibited selective inhibitory activity against isocitrate dehydrogenase mutant R132H (IDH1m), with IC₅₀ values of 41.9 and 27.7 μM, respectively. Our findings thus provide a fresh incentive for investigation on IDH1m inhibitors as lead compounds for cancer treatment.

Keywords: Coral derived fungus; isocitrate dehydrogenase; polyketide; secondary metabolites.