The liver synthesizes and releases bile acids into the gut. Bile acids, either directly or indirectly, inhibit agouti-related peptide (AGRP)-B cells in the pars tuberalis of the pituitary gland. AGRP-B cells are assumed to promote pancreatic insulin secretion and/or to improve insulin sensitivities in insulin sensitive organs, resulting in improved glucose tolerance.
© 2023 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.