Research advances in pathogenic mechanisms underlying air pollution-induced ocular surface diseases

Fan Song; Shengjie Hao; Yuzhou Gu; Ke Yao; Qiuli Fu

doi:10.1016/j.aopr.2021.100001

Research advances in pathogenic mechanisms underlying air pollution-induced ocular surface diseases

Adv Ophthalmol Pract Res. 2021 Aug 11;1(1):100001. doi: 10.1016/j.aopr.2021.100001. eCollection 2021 Nov.

Authors

Fan Song^{1

2}, Shengjie Hao^{1

2}, Yuzhou Gu^{1

2}, Ke Yao^{1

2}, Qiuli Fu^{1

2}

Affiliations

¹ Eye Center of the 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
² Zhejiang Provincial Key Lab of Ophthalmology, Hangzhou, Zhejiang Province, China.

Abstract

Background: The harmful effect of aerial fine particulate matter（PM_2.5）has been a serious public health issue and has attracted worldwide attention, especially in developing countries.

Main text: Numerous previous clinical and experimental studies have demonstrated that PM_2.5 has a clear pathogenic effect on diseases related to the respiratory and cardiovascular systems. Recent researches have pointed out that PM_2.5 plays a pivotal role in the occurrence and progression of ocular surface diseases. The current studies have shown that PM_2.5 may promote the appearance of conjunctivitis, keratitis, blepharitis, dry eye, meibomian gland dysfunction（MGD） and other ocular surface diseases through regulating a series of mechanisms such as inflammation, immune reaction, oxidative stress, autophagy, cell migration, and epigenetics.

Conclusions: This review aims to summarize the current research progress on the pathogenic mechanism of PM_2.5-related ocular surface diseases.

Keywords: Air pollutuion; Mechanism; Ocular surface diseases; PM2.5.

Publication types

Review