Experimental and modeling of solubility of sitagliptin phosphate, in supercritical carbon dioxide: proposing a new association model

Nedasadat Saadati Ardestani; Seyed Ali Sajadian; Nadia Esfandiari; Adrián Rojas; Chandrasekhar Garlapati

doi:10.1038/s41598-023-44787-z

Experimental and modeling of solubility of sitagliptin phosphate, in supercritical carbon dioxide: proposing a new association model

Sci Rep. 2023 Oct 16;13(1):17506. doi: 10.1038/s41598-023-44787-z.

Authors

Nedasadat Saadati Ardestani¹, Seyed Ali Sajadian^{2

3}, Nadia Esfandiari⁴, Adrián Rojas^{5

6}, Chandrasekhar Garlapati⁷

Affiliations

¹ Nanotechnology Research Center, Research Institute of Petroleum Industry (RIPI), 14857-336, Tehran, Iran.
² Department of Chemical Engineering, Faculty of Engineering, University of Kashan, Kashan, 87317-53153, Iran. seyedali.sajadian@gmail.com.
³ South Zagros Oil and Gas Production, National Iranian Oil Company, Shiraz, 7135717991, Iran. seyedali.sajadian@gmail.com.
⁴ Department of Chemical Engineering, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran.
⁵ Department of Science and Food Technology, Faculty of Technology, Packaging Innovation Center (LABEN), University of Santiago of Chile (USACH), Obispo Umaña 050, 9170201, Santiago, Chile.
⁶ Center for the Development of Nanoscience and Nanotechnology (CEDENNA), 9170124, Santiago, Chile.
⁷ Department of Chemical Engineering, Puducherry Technological University, Puducherry, 605014, India. chandrasekhar@ptuniv.edu.in.

Abstract

The solubility of an anti-hyperglycemic agent drug, (R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro [1,2,4] triazolo[4,3-a] pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl) butan-2-amine (also known as Sitagliptin phosphate) in supercritical carbon dioxide (scCO₂) was determined by ananalytical and dynamic technique at different temperatures (308, 318, 328 and 338 K) and pressure (12-30 MPa) values. The measured solubilities were in the range of 3.02 × 10^-5 to 5.17 × 10^-5, 2.71 × 10^-5 to 5.83 × 10^-5, 2.39 × 10^-5 to 6.51 × 10^-5 and 2.07 × 10^-5 to 6.98 × 10^-5 in mole fraction at (308, 318, 328 and 338) K, respectively. The solubility data were correlated with existing density models and with a new association model.