Isolated hyperthermic perfusions for cutaneous melanoma in-transit metastasis of the limb and uveal melanoma metastasis to the liver

Anne Huibers; Danielle K DePalo; Matthew C Perez; Jonathan S Zager; Roger Olofsson Bagge

doi:10.1007/s10585-023-10234-6

Isolated hyperthermic perfusions for cutaneous melanoma in-transit metastasis of the limb and uveal melanoma metastasis to the liver

Clin Exp Metastasis. 2023 Oct 16. doi: 10.1007/s10585-023-10234-6. Online ahead of print.

Authors

Anne Huibers^{1

2}, Danielle K DePalo³, Matthew C Perez³, Jonathan S Zager^{3

4}, Roger Olofsson Bagge^{5

6}

Affiliations

¹ Department of Surgery, Sahlgrenska University Hospital, 413 45, Gothenburg, Sweden.
² Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 413 90, Gothenburg, Sweden.
³ Department of Cutaneous Oncology, Moffitt Cancer Center, Tampa, FL, USA.
⁴ Department of Oncologic Sciences, University of South Florida Morsani, College of Medicine, Tampa, FL, USA.
⁵ Department of Surgery, Sahlgrenska University Hospital, 413 45, Gothenburg, Sweden. roger.olofsson.bagge@gu.se.
⁶ Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 413 90, Gothenburg, Sweden. roger.olofsson.bagge@gu.se.

PMID: 37843790
DOI: 10.1007/s10585-023-10234-6

Abstract

Patients with cutaneous melanoma can develop in-transit metastases (ITM), most often localized to limbs. For patients with uveal melanoma that develop metastatic disease, the overall majority develop isolated liver metastases. For these types of metastases, regional cancer therapies have evolved as effective treatments. Isolated limb perfusion (ILP), isolated limb infusion (ILI), isolated hepatic perfusion (IHP) and percutaneous hepatic perfusion (PHP) achieve a high local concentration of chemotherapy with minimal systemic exposure. This review discusses the mechanism and available literature on locoregional treatment modalities in the era of modern immunotherapy.

Keywords: In transit metastasis; Isolated hepatic perfusion; Isolated limb infusion; Isolated limb perfusion; Percutaneous hepatic perfusion; Uveal melanoma.

Publication types

Review