Abstract
A new quinochalcone C-glycoside featuring a unique quinonoid moiety, named celochalcoside (1), was isolated from the n-butanol extract of the aerial parts of Celosia trigyna L. The structure was determined by extensive spectroscopic analysis as well as mass spectrometric data. Compound 1 showed moderate cytotoxic activities against breast cancer cell lines (MCF-7), colon cancer cell lines (HT-29) and hepatocellular carcinoma cell lines (HepG2) with IC50 values of 23.16, 37.05 and 18.35 μg/ml, respectively.
Keywords:
Amaranthaceae; Celosia trigyna; NMR; cytotoxicity; quinochalcone-C-glycoside.
MeSH terms
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Antineoplastic Agents, Phytogenic* / chemistry
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Antineoplastic Agents, Phytogenic* / isolation & purification
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Antineoplastic Agents, Phytogenic* / pharmacology
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Celosia* / chemistry
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Chalcones* / chemistry
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Chalcones* / isolation & purification
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Chalcones* / pharmacology
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Drug Screening Assays, Antitumor*
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Drugs, Chinese Herbal* / chemistry
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Drugs, Chinese Herbal* / isolation & purification
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Drugs, Chinese Herbal* / pharmacology
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Female
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Glycosides* / chemistry
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Glycosides* / isolation & purification
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Glycosides* / pharmacology
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HT29 Cells
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Hep G2 Cells
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Humans
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MCF-7 Cells
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
Substances
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Glycosides
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Antineoplastic Agents, Phytogenic
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Chalcones
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Drugs, Chinese Herbal
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C-glycoside