Comparison of treatment outcomes between intermittent and daily regimens in non-cavitary nodular bronchiectatic-type Mycobacterium avium complex pulmonary disease in relation to sputum smear results: a retrospective cohort study

Antimicrob Agents Chemother. 2023 Nov 15;67(11):e0100323. doi: 10.1128/aac.01003-23. Epub 2023 Oct 16.

Abstract

This study retrospectively analyzed the treatment outcomes of 110 patients with non-cavitary nodular bronchiectatic-type Mycobacterium avium complex pulmonary disease who received intermittent or daily treatment with a three-drug oral antibiotic regimen (i.e., a macrolide, ethambutol, and rifampin) at a tertiary referral center in South Korea. Among these patients, 36 had sputum smear positivity. Of these 36 patients, intermittent treatment led to a lower culture conversion rate than daily treatment [50.0% (8/16) vs 85.0% (17/20), P = 0.034].

Keywords: AFB smear positivity; Mycobacterium avium complex; intermittent; non-cavitary nodular bronchiectatic type.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Bronchiectasis* / drug therapy
  • Bronchiectasis* / microbiology
  • Humans
  • Lung Diseases* / drug therapy
  • Lung Diseases* / microbiology
  • Mycobacterium avium Complex
  • Mycobacterium avium-intracellulare Infection* / drug therapy
  • Mycobacterium avium-intracellulare Infection* / microbiology
  • Retrospective Studies
  • Sputum / microbiology
  • Treatment Outcome

Substances

  • Anti-Bacterial Agents