Exploring the Potential of Natural Products as Antiparasitic Agents for Neglected Tropical Diseases

Curr Top Med Chem. 2024;24(2):89-108. doi: 10.2174/0115680266256963230921061925.

Abstract

Recent developments in the use of natural product-based molecules as antiparasitic agents for Malaria, leishmaniasis (LE), Chagas disease (CD), and Human African trypanosomiasis (HAT) are reviewed. The role of diverse plants in developing bioactive species is discussed in addition to analyzing the structural diversity of natural products as active agents and the diverse biological applications in CD, HAT, LE, and Malaria. This review focuses on medicinal chemistry, emphasizing the structural characteristics of natural molecules as bioactive agents against parasitic infections caused by Leishmania, Trypanosoma, and Plasmodium parasites.

Keywords: Chagas; Leishmaniasis; Malaria; Marine compounds; Natural compounds; Vegetal compounds..

Publication types

  • Review

MeSH terms

  • Animals
  • Antiparasitic Agents / chemistry
  • Antiparasitic Agents / pharmacology
  • Antiparasitic Agents / therapeutic use
  • Antiprotozoal Agents* / chemistry
  • Antiprotozoal Agents* / pharmacology
  • Antiprotozoal Agents* / therapeutic use
  • Biological Products* / chemistry
  • Biological Products* / pharmacology
  • Biological Products* / therapeutic use
  • Chagas Disease* / drug therapy
  • Humans
  • Leishmaniasis* / drug therapy
  • Malaria* / drug therapy
  • Neglected Diseases / drug therapy
  • Neglected Diseases / parasitology
  • Trypanosomiasis, African* / drug therapy

Substances

  • Antiparasitic Agents
  • Antiprotozoal Agents
  • Biological Products