Research progress of NF-κB signaling pathway and thrombosis

Zilong Wang; Chucun Fang; Mengting Yao; Dongwen Wu; Maga Chen; Tianting Guo; Jianwen Mo

doi:10.3389/fimmu.2023.1257988

Research progress of NF-κB signaling pathway and thrombosis

Front Immunol. 2023 Sep 29:14:1257988. doi: 10.3389/fimmu.2023.1257988. eCollection 2023.

Authors

Zilong Wang¹, Chucun Fang¹, Mengting Yao¹, Dongwen Wu¹, Maga Chen¹, Tianting Guo², Jianwen Mo³

Affiliations

¹ The First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, China.
² Department of Orthopedics, Ganzhou City Hospital, Ganzhou, Jiangxi, China.
³ Department of Orthopedics, The First Affiliated Hospital of Gannan Medical College, Ganzhou, Jiangxi, China.

Abstract

Venous thromboembolism is a very common and costly health problem. Deep-vein thrombosis (DVT) can cause permanent damage to the venous system and lead to swelling, ulceration, gangrene, and other symptoms in the affected limb. In addition, more than half of the embolus of pulmonary embolism comes from venous thrombosis, which is the most serious cause of death, second only to ischemic heart disease and stroke patients. It can be seen that deep-vein thrombosis has become a serious disease affecting human health. In recent years, with the deepening of research, inflammatory response is considered to be an important pathway to trigger venous thromboembolism, in which the transcription factor NF-κB is the central medium of inflammation, and the NF-κB signaling pathway can regulate the pro-inflammatory and coagulation response. Thus, to explore the mechanism and make use of it may provide new solutions for the prevention and treatment of thrombosis.

Keywords: NF-κB signal pathway; TCM; drugs; inflammation; miRNA; natural compounds; thrombosis.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Humans
NF-kappa B
Signal Transduction
Thrombosis* / etiology
Venous Thromboembolism* / prevention & control
Venous Thrombosis*

Substances

NF-kappa B

Grants and funding

The authors declare financial support was received for the research, authorship, and/or publication of this article. This research was supported by the National Natural Science Foundation of China (Approval/Award No. 82160375), the Natural Science Foundation of Jiangxi Province (Approval/Award No. 20202BABL206035), and the project funded by the Department of Education of Jiangxi Province (Approval/Award No. GJJ180811).