Synthesis of cyano and ionic dual-functional hypercrosslinked porous polymer for effective adsorption and detection of endocrine disrupting chemicals in milk matrix

Zixuan Cai; Zhi Li; Qianqian Wang; Zhi Wang; Qiuhua Wu; Chun Wang

doi:10.1016/j.jhazmat.2023.132746

Synthesis of cyano and ionic dual-functional hypercrosslinked porous polymer for effective adsorption and detection of endocrine disrupting chemicals in milk matrix

J Hazard Mater. 2024 Jan 15:462:132746. doi: 10.1016/j.jhazmat.2023.132746. Epub 2023 Oct 11.

Authors

Zixuan Cai¹, Zhi Li¹, Qianqian Wang¹, Zhi Wang², Qiuhua Wu², Chun Wang³

Affiliations

¹ Department of Chemistry, College of Science, Hebei Agricultural University, Baoding 071001, China.
² Department of Chemistry, College of Science, Hebei Agricultural University, Baoding 071001, China; Department of Food Science, College of Food Science and Technology, Hebei Agricultural University, Baoding 071001, China.
³ Department of Chemistry, College of Science, Hebei Agricultural University, Baoding 071001, China. Electronic address: wangchun@hebau.edu.cn.

PMID: 37832438
DOI: 10.1016/j.jhazmat.2023.132746

Abstract

Endocrine disrupting chemicals (EDCs) can interfere with the normal function of endocrine system, posing serious risk to human health. The monitoring of EDCs in foods is of great importance to ensure food security. Herein, a cyano and ionic dual-functionalized hypercrosslinked porous polymer (CN-iHCP) was designed and prepared for the first time through hyper-crosslink of 1-(4-cyanophenyl)imidazole and 1,4-bis(chloromethyl)benzene. The adsorption mechanism mainly involves electrostatic interaction, hydrogen bonding and π-π stacking interaction. A sensitive analytical method for simultaneous detection of the four phenolic EDCs was established by coupled CN-iHCP based solid-phase extraction with high performance liquid chromatography. Under optimal conditions, the target EDCs exhibited good linearity with coefficient r > 0.993 and high enrichment factors of 164-243. The detection limits (S/N = 3) of EDCs were 0.20-0.50 ng mL^-1 for milk sample. The extraction recoveries for the spiked milk samples were in the range of 85.5%- 116.0%. This work not only highlights the CN-iHCP as a promising adsorbent to efficiently enrich EDCs and other pollutants, but also provides a new strategy for the functionalization of HCP for wide applications.

Keywords: Endocrine disrupting chemicals; High performance liquid chromatography; Ionic hypercrosslinked polymer; Milk; Solid phase extraction.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adsorption
Animals
Chromatography, High Pressure Liquid / methods
Endocrine Disruptors* / chemistry
Humans
Limit of Detection
Milk* / chemistry
Polymers / chemistry
Porosity
Solid Phase Extraction / methods

Substances

Endocrine Disruptors
Polymers