Ultrasensitive electrochemiluminescence sensor for the detection of synthetic cannabinoids based on perovskite as coreaction accelerator and light-scattering effects of photonic crystals

Xiaomei An; Ding Jiang; Qianying Cao; Wenchang Wang; Fangmin Xu; Hiroshi Shiigi; Zhidong Chen

doi:10.1016/j.aca.2023.341852

Ultrasensitive electrochemiluminescence sensor for the detection of synthetic cannabinoids based on perovskite as coreaction accelerator and light-scattering effects of photonic crystals

Anal Chim Acta. 2023 Oct 23:1279:341852. doi: 10.1016/j.aca.2023.341852. Epub 2023 Sep 27.

Authors

Xiaomei An¹, Ding Jiang², Qianying Cao¹, Wenchang Wang², Fangmin Xu³, Hiroshi Shiigi⁴, Zhidong Chen⁵

Affiliations

¹ Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, School of Petrochemical Engineering, Changzhou University, Changzhou, 213164, China.
² Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, School of Petrochemical Engineering, Changzhou University, Changzhou, 213164, China; Advanced Catalysis and Green Manufacturing Collaborative Innovation Center, Changzhou University, Changzhou, 213164, China.
³ Institute of Forensic Science, Public Security Bureau of Jiangyin, Wuxi, 214431, China.
⁴ Osaka Metropolitan University, Department of Applied Chemistry, Naka Ku, 1-1 Gakuen, Naka, Sakai, Osaka, 599-8531, Japan.
⁵ Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, School of Petrochemical Engineering, Changzhou University, Changzhou, 213164, China; Advanced Catalysis and Green Manufacturing Collaborative Innovation Center, Changzhou University, Changzhou, 213164, China. Electronic address: zdchen@cczu.edu.cn.

PMID: 37827658
DOI: 10.1016/j.aca.2023.341852

Abstract

As is common knowledge, a strong electrochemiluminescence (ECL) signal is required to ensure the high sensitivity of trace target detection. Here, a dual signal amplification strategy by integrating of perovskite and photonic crystal was fabricated for quantitative synthetic cannabinoids (AB-PINACA) detection based on Zr-connected PTCA and TCPP (PTCA-TCPP) with excellent ECL performance as luminophores. On the one hand, the co-reaction accelerator perovskite (LaCoO₃) improved the effective electroactive area of the electrode and promoted the decomposition of K₂S₂O₈, resulting in a stronger ECL signal value. On the other hand, polystyrene inverse opal (PIOPCs) formed after the swelling of PS microspheres not only taken advantage of the light scattering effect and excellent catalytic property of photonic crystals to amplify the ECL signal, but also could be used as a binder to fix LaCoO₃ and PTCA-TCPP on the electrode surface to generate unprecedented ECL response and stable ECL signals. Subsequently, the detection substance AB-PINACA was loaded on the electrode surface via the amide bond with the luminophores PTCA-TCPP, thus quenching the ECL signal, so as to realize the sensitive detection of synthetic cannabinoids. Under the optimal conditions, the proposed sensor achieved highly sensitive AB-PINACA detection with a dynamic range from 1.0 × 10^-12 to 1.0 × 10^-3 g/L and the detection limit was 1.1 × 10^-13 g/L, which had great application potential in the detection of synthetic cannabinoids.

Keywords: Coreaction accelerator; Dual signal amplification; Electrochemiluminescence; Light-scattering effects; Synthetic cannabinoids.