Finegoldia magna and Mucorales molds co-infection in a severe case of SARS-CoV-2 disease

J Infect Dev Ctries. 2023 Sep 30;17(9):1231-1236. doi: 10.3855/jidc.17647.

Abstract

Introduction: Rhino-orbito-cerebral mucormycosis has been reported as a sequela after coronavirus disease in immunocompromised patients with poorly controlled diabetes mellitus. Most cases have been identified in India, with only 19 reported elsewhere.

Methodology: We herein report the results of clinical, imaging, microbiological, and histopathological studies in an immunocompetent 67-year-old male with rhino-orbital infection by Finegoldia magna and Mucorales molds following severe SARS-CoV-2 disease associated with new-onset decompensated diabetes mellitus.

Results: Microbiological and histological studies confirmed the presence of both Mucorales molds and Finegoldia magna, which was successfully treated with antibiotics and a specific anti-fungal agent (Posaconazole).

Conclusions: Careful multidisciplinary follow-up of patients treated for severe SARS-CoV-2 disease is necessary for the timely diagnosis of complications such as uncontrolled diabetes mellitus and opportunistic infections.

Keywords: COVID-19; SARS-CoV-2; mucomycosis; rhino-orbital infection.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antifungal Agents
  • COVID-19* / complications
  • COVID-19* / diagnosis
  • Coinfection* / diagnosis
  • Diabetes Mellitus*
  • Humans
  • Male
  • Mucorales*
  • Mucormycosis* / complications
  • Mucormycosis* / diagnosis
  • Mucormycosis* / drug therapy
  • SARS-CoV-2

Substances

  • Antifungal Agents

Supplementary concepts

  • Finegoldia magna