Activated protein C signaling mediates neuroinflammation in seizure induced by pilocarpine

Linda Ines Zoungrana; Meredith Krause-Hauch; Hao Wang; Mohammad Kasim Fatmi; Zehui Li; Lily Slotabec; Adewale Segun James; Steven Didik; Ji Li

doi:10.1016/j.bbrep.2023.101550

Activated protein C signaling mediates neuroinflammation in seizure induced by pilocarpine

Biochem Biophys Rep. 2023 Sep 29:35:101550. doi: 10.1016/j.bbrep.2023.101550. eCollection 2023 Sep.

Authors

Linda Ines Zoungrana¹, Meredith Krause-Hauch¹, Hao Wang², Mohammad Kasim Fatmi¹, Zehui Li¹, Lily Slotabec², Adewale Segun James¹, Steven Didik¹, Ji Li²

Affiliations

¹ Department of Surgery, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, USA.
² Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, 39216, USA.

Abstract

Epilepsy is one of the most common and oldest neurological disorders, characterized by periodic seizures that affect millions globally. Despite its long history, its pathophysiology is not fully understood. Additionally, the current treatment methods have their limitations. Finding a new alternative is necessary. Activated Protein C (APC) has been proven to have neurological protection in other neurological disorders; however, there is no study that focuses on the role of APC in seizures. We propose that APC's protective effect could be associated with seizures through inflammation and apoptosis regulation. The results demonstrated that APC's pathway proteins are involved in neuroprotection mechanisms in seizure-induced models by acting on certain inflammatory factors, such as NF-κB and apoptosis proteins.

Keywords: Activated protein C; Epilepsy; Inflammation.

Abstract

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