Characteristics of Vitreoretinal Lymphoma in B-Scan Ultrasonography: A Case-Control Study

Junxiang Gu; Qian Chen; Peijun Zhang; Ting Zhang; Xinyi Zhou; Kaiyu Zhang; Tingting Jiang; Shixue Liu; Wenwen Chen; Min Zhou; Rui Jiang; Xin Huang; Gezhi Xu; Qing Chang

doi:10.1016/j.oret.2023.10.002

Characteristics of Vitreoretinal Lymphoma in B-Scan Ultrasonography: A Case-Control Study

Ophthalmol Retina. 2024 Mar;8(3):264-269. doi: 10.1016/j.oret.2023.10.002. Epub 2023 Nov 18.

Authors

Junxiang Gu¹, Qian Chen¹, Peijun Zhang¹, Ting Zhang¹, Xinyi Zhou², Kaiyu Zhang², Tingting Jiang¹, Shixue Liu¹, Wenwen Chen¹, Min Zhou¹, Rui Jiang¹, Xin Huang¹, Gezhi Xu¹, Qing Chang³

Affiliations

¹ Department of Ophthalmology, Fudan University Eye and ENT Hospital, Fudan University, Shanghai, China; Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University Eye and ENT Hospital, Fudan University, Shanghai, China; NHC Key Laboratory of Myopia (Fudan University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China.
² Shanghai Medical College, Fudan University, Shanghai, China.
³ Department of Ophthalmology, Fudan University Eye and ENT Hospital, Fudan University, Shanghai, China; Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University Eye and ENT Hospital, Fudan University, Shanghai, China; NHC Key Laboratory of Myopia (Fudan University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China. Electronic address: qngchang@aliyun.com.

PMID: 37820767
DOI: 10.1016/j.oret.2023.10.002

Abstract

Purpose: To explore the characteristics of vitreoretinal lymphoma (VRL) in B-scan ultrasonography.

Design: Single-center case-control study.

Participants: A total of 106 eyes of 56 patients with biopsy-proven VRL and 86 eyes of 59 patients with uveitis were included.

Methods: B-scan ultrasonography of the included eyes was performed. Evaluated were the ultrasonographic signs as well as a special pattern termed centrifugal condensation, which refers to the peripherally hyperreflective appearance of the vitreous haze in ultrasonography.

Main outcome measures: Posterior vitreous detachment, vitreoretinal adhesion, location of vitreous haze, thickening or occupying lesions of the retina, retinal detachment, and centrifugal condensation pattern of vitreous haze were evaluated through B-scan ultrasonography. The incidences of these signs were compared between the 2 groups; odds ratios (ORs) were calculated.

Results: The incidence of vitreoretinal adhesion in patients with VRL (6/106) was lower than in patients with uveitis (20/86; P = 0.001; OR: 0.195; 95% confidence interval [CI]: 0.073-0.522). The incidence of retinal thickening or occupying lesions in patients with VRL (21/106) was higher than that in patients with uveitis (1/86; P = 0.005; OR: 19.068; 95% CI: 2.455-148.265). The incidences of posterior vitreous detachment and retinal detachment were not significantly different between the 2 groups (P = 0.453 and P = 0.310, respectively). The centrifugal condensation pattern was more likely to be observed in patients with VRL (49/106) than in patients with uveitis (13/86; P < 0.001; OR: 4.831; 95% CI: 2.416-9.660).

Conclusions: B-scan ultrasonography might help to provide clues for the suspicion of VRL. Thickening or occupying lesions of the retina and centrifugal condensation pattern of vitreous haze might be suggestive of VRL.

Financial disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Keywords: B-scan ultrasonography; Vitreoretinal lymphoma; Vitreous haze.

MeSH terms

Case-Control Studies
Endophthalmitis*
Eye Neoplasms*
Humans
Lymphoma* / diagnosis
Retinal Detachment* / pathology
Retinal Diseases* / pathology
Retinal Neoplasms* / diagnosis
Retinal Neoplasms* / pathology
Ultrasonography
Uveitis* / diagnosis
Vitreous Body / diagnostic imaging
Vitreous Body / pathology
Vitreous Detachment* / diagnosis
Vitreous Detachment* / etiology
Vitreous Detachment* / pathology