A review of research progress on mechanisms of peritoneal fibrosis related to peritoneal dialysis

Jin'e Li; Yinghong Liu; Jianping Liu

doi:10.3389/fphys.2023.1220450

A review of research progress on mechanisms of peritoneal fibrosis related to peritoneal dialysis

Front Physiol. 2023 Sep 25:14:1220450. doi: 10.3389/fphys.2023.1220450. eCollection 2023.

Authors

Jin'e Li^{1

2}, Yinghong Liu³, Jianping Liu¹

Affiliations

¹ Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
² Jiangxi Medical College, Nanchang University, Nanchang, China.
³ Department of Nephrology, Second Xiangya Hospital, Central South University, Changsha, China.

Abstract

Peritoneal dialysis (PD) is an effective alternative treatment for patients with end-stage renal disease (ESRD) and is increasingly being adopted and promoted worldwide. However, as the duration of peritoneal dialysis extends, it can expose problems with dialysis inadequacy and ultrafiltration failure. The exact mechanism and aetiology of ultrafiltration failure have been of great concern, with triggers such as biological incompatibility of peritoneal dialysis solutions, uraemia toxins, and recurrent intraperitoneal inflammation initiating multiple pathways that regulate the release of various cytokines, promote the transcription of fibrosis-related genes, and deposit extracellular matrix. As a result, peritoneal fibrosis occurs. Exploring the pathogenic factors and molecular mechanisms can help us prevent peritoneal fibrosis and prolong the duration of Peritoneal dialysis.

Keywords: EMT; TGF-β1; mechanism; peritoneal dialysis; peritoneal fibrosis.

Publication types

Review

Grants and funding

This work was supported by the National Natural Science Foundation of China (Grant Nos. 82160162, and 81760150) and the Key Project of Jiangxi Provincial Natural Science Foundation (Grant No. 20202ACBL206008).