De Novo Crohn's Disease in the Pediatric Pouch

Delia O'Shea; Joseph A Picoraro

doi:10.1093/ibd/izad231

De Novo Crohn's Disease in the Pediatric Pouch

Inflamm Bowel Dis. 2023 Oct 10:izad231. doi: 10.1093/ibd/izad231. Online ahead of print.

Authors

Delia O'Shea¹, Joseph A Picoraro¹

Affiliation

¹ Division of Pediatric Gastroenterology, Hepatology and Nutrition, Columbia University Irving Medical Center, NewYork-Presbyterian Hospital, New York, NY, USA.

PMID: 37815461
DOI: 10.1093/ibd/izad231

Abstract

Children who undergo ileal pouch anal anastomosis (IPAA) surgery for refractory ulcerative colitis (UC) may ultimately develop a Crohn's disease (CD) phenotype. This de novo CD is open to broad interpretation and misattribution, and its manifestation in children is poorly understood. The surgically altered environment of the ileal pouch is at risk of a spectrum of ileal pouch disorders, which have limited description in children. In this issue of Inflammatory Bowel Diseases, a multicenter, retrospective study of children with UC who underwent IPAA and developed de novo CD highlights the challenges and opportunities of ileal pouch characterization in children.

Keywords: IPAA; de novo Crohn’s disease; ileal pouch; pediatric inflammatory bowel disease; pouchitis.

Plain language summary

In this issue of Inflammatory Bowel Diseases, a multicenter, retrospective study provides insight into the poorly understood circumstances in which children who have undergone ileal pouch anal anastomosis surgery for refractory ulcerative colitis develop a Crohn’s disease phenotype.