The Biological Significance Of AFF4: Promoting Transcription Elongation, Osteogenic Differentiation and Tumor Progression

Qian Long; Mingli Xiang; Linlin Xiao; Jiajia Wang; Xiaoyan Guan; Jianguo Liu; Chengcheng Liao

doi:10.2174/0113862073241079230920082056

The Biological Significance Of AFF4: Promoting Transcription Elongation, Osteogenic Differentiation and Tumor Progression

Comb Chem High Throughput Screen. 2023 Oct 5. doi: 10.2174/0113862073241079230920082056. Online ahead of print.

Authors

Qian Long¹, Mingli Xiang¹, Linlin Xiao¹, Jiajia Wang¹, Xiaoyan Guan¹, Jianguo Liu², Chengcheng Liao¹

Affiliations

¹ Zunyi Medical University Department of Orthodontics II, Affiliated Stomatological Hospital of Zunyi Medical University Zunyi China.
² Zunyi Medical University Oral Disease Research Key Laboratory of Guizhou Tertiary Institution Zunyi China.

PMID: 37815186
DOI: 10.2174/0113862073241079230920082056

Abstract

As a member of the AF4/FMR2 (AFF) family, AFF4 is a scaffold protein in the superelongation complex (SEC). In this mini-view, we discuss the role of AFF4 as a transcription elongation factor that mediates HIV activation and replication and stem cell osteogenic differentiation. AFF4 also promotes the progression of head and neck squamous cell carcinoma, leukemia, breast cancer, bladder cancer and other malignant tumors. The biological function of AFF4 is largely achieved through SEC assembly, regulates SRY-box transcription factor 2 (SOX2), MYC, estrogen receptor alpha (ESR1), inhibitor of differentiation 1 (ID1), c-Jun and noncanonical nuclear factor-κB (NF-κB) transcription and combines with fusion in sarcoma (FUS), unique regulatory cyclins (CycT1), or mixed lineage leukemia (MLL). We explore the prospects of using AFF4 as a therapeutic in Acquired immunodeficiency syndrome (AIDS) and malignant tumors and its potential as a stemness regulator.

Keywords: AFF4; SEC; osteogenic differentiation; transcription elongation; tumor.