Ru(II)-Catalyzed N-Methylation of Amines Using Methanol as the C1 Source

Caiyu Gao; Yufei Li; Minghao Wang; Dawei Gong; Lina Zhao

doi:10.1021/acsomega.3c06260

Ru(II)-Catalyzed N-Methylation of Amines Using Methanol as the C1 Source

ACS Omega. 2023 Sep 20;8(39):36597-36603. doi: 10.1021/acsomega.3c06260. eCollection 2023 Oct 3.

Authors

Caiyu Gao¹, Yufei Li¹, Minghao Wang¹, Dawei Gong¹, Lina Zhao¹

Affiliation

¹ Key Laboratory of Preparation and Application of Environmental Friendly Materials, Ministry of Education, College of Chemistry, Jilin Normal University, Changchun 130103, P. R. China.

Abstract

Four ruthenium complexes were used as catalysts for the N-methylation of amines using methanol as the C1 source under weak base conditions. The (DPEPhos)RuCl₂PPh₃(1a) catalyst showed the best catalytic performance (0.5 mol %, 12 h). The deuterium labeling and control experiments suggested the reaction via the Ru-H mechanism. This study provides a new ruthenium catalyst system for N-methylation with methanol under weak base conditions.