Urinary exosomes: a promising biomarker of drug-induced nephrotoxicity

Zunzhen Zhou; Dailiang Zhang; Yongjing Wang; Chongzhi Liu; Limei Wang; Yi Yuan; Xiaodan Xu; Yuan Jiang

doi:10.3389/fmed.2023.1251839

Urinary exosomes: a promising biomarker of drug-induced nephrotoxicity

Front Med (Lausanne). 2023 Sep 22:10:1251839. doi: 10.3389/fmed.2023.1251839. eCollection 2023.

Authors

Zunzhen Zhou¹, Dailiang Zhang¹, Yongjing Wang¹, Chongzhi Liu¹, Limei Wang^{1

2}, Yi Yuan³, Xiaodan Xu¹, Yuan Jiang¹

Affiliations

¹ Clinical Medical College, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China.
² Department of Rehabilitation Medicine, The Third Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China.
³ Orthopedic Department, Dazhou Integrated TCM and Western Medicine Hospital, Dazhou Second People's Hospital, Dazhou, China.

Abstract

Drug-induced nephrotoxicity (DIN) is a big concern for clinical medication, but the clinical use of certain nephrotoxic drugs is still inevitable. Current testing methods make it hard to detect early renal injury accurately. In addition to understanding the pathogenesis and risk factors of drug-induced nephrotoxicity, it is crucial to identify specific renal injury biomarkers for early detection of DIN. Urine is an ideal sample source for biomarkers related to kidney disease, and urinary exosomes have great potential as biomarkers for predicting DIN, which has attracted the attention of many scholars. In the present paper, we will first introduce the mechanism of DIN and the biogenesis of urinary exosomes. Finally, we will discuss the changes in urinary exosomes in DIN and compare them with other predictive indicators to enrich and boost the development of biomarkers of DIN.

Keywords: acute kidney injury; biomarkers; drug-induced nephrotoxicity; kidney disease; urinary exosomes.

Publication types

Review

Grants and funding

This work was supported by the grants from Research project of the Science and Technology Department of Sichuan province (2021YJ0217), Research Project of Sichuan Applied Psychology Research Center of Chengdu Medical College (CSXL-202A13), Dazhou Science and Technology Plan Project - Key R&D Plan (22ZDYF0050).