STING channels its proton power

Mingqi Dong; Katherine A Fitzgerald

doi:10.1016/j.molcel.2023.09.014

STING channels its proton power

Mol Cell. 2023 Oct 5;83(19):3402-3403. doi: 10.1016/j.molcel.2023.09.014.

Authors

Mingqi Dong¹, Katherine A Fitzgerald²

Affiliations

¹ Division of Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
² Division of Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA. Electronic address: kate.fitzgerald@umassmed.edu.

PMID: 37802022
DOI: 10.1016/j.molcel.2023.09.014

Abstract

Induction of type I interferon by the STING pathway is a cornerstone of innate immunity. STING also turns on non-canonical autophagy and inflammasome activation although the underlying mechanisms remain ill defined. Liu et al.¹ discovered that STING forms a channel that directs proton efflux from the Golgi to drive these responses.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Immunity, Innate
Inflammasomes
Interferon Type I*
Membrane Proteins* / metabolism
Nucleotidyltransferases
Protons

Substances

Membrane Proteins
Protons
Inflammasomes
Interferon Type I
Nucleotidyltransferases