Wernicke Encephalopathy After Bariatric Surgery: a Literature Review

Obes Surg. 2023 Nov;33(11):3621-3627. doi: 10.1007/s11695-023-06840-8. Epub 2023 Oct 6.

Abstract

Wernicke encephalopathy (WE) is an acute neurological disorder classically characterized by ataxia, ophthalmoplegia, and altered mental status. This is caused by thiamine deficiency and is usually seen in malnourished populations. However, with the advent and rise of bariatric surgery in the last 50 years, WE has become an increasingly recognized and potentially deadly complication. Here, we review the populations at risk, clinical presentation, and the incidence of WE in the bariatric surgery population from 1985 to 2023. While the predominant procedure shifts throughout the years, the overall incidence of WE per 100,000 cases for the following procedures are sleeve gastrectomy (1.06), gastric band (1.16), RYGB (4.29), and biliopancreatic diversion with duodenal switch (8.92). Thus, early intervention and post-operative supplementation is recommended to prevent WE.

Keywords: Bariatric surgery; Obesity; Thiamine; Wernicke encephalopathy.

Publication types

  • Review

MeSH terms

  • Bariatric Surgery* / adverse effects
  • Biliopancreatic Diversion* / adverse effects
  • Gastrectomy / adverse effects
  • Humans
  • Obesity, Morbid* / surgery
  • Thiamine Deficiency* / etiology
  • Wernicke Encephalopathy* / etiology
  • Wernicke Encephalopathy* / prevention & control