Review: Non-canonical role of Drosha ribonuclease III

Xuanshuo Wei; Jin Tang; Chuwen Lin; Xuan Jiang

doi:10.1016/j.ijbiomac.2023.127202

Review: Non-canonical role of Drosha ribonuclease III

Int J Biol Macromol. 2023 Dec 31;253(Pt 5):127202. doi: 10.1016/j.ijbiomac.2023.127202. Epub 2023 Oct 2.

Authors

Xuanshuo Wei¹, Jin Tang¹, Chuwen Lin¹, Xuan Jiang²

Affiliations

¹ Shenzhen Key Laboratory for Systems Medicine in Inflammatory Diseases, School of Medicine, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, 518107, Guangdong, China.
² Shenzhen Key Laboratory for Systems Medicine in Inflammatory Diseases, School of Medicine, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, 518107, Guangdong, China. Electronic address: jiangx79@mail.sysu.edu.cn.

PMID: 37793530
DOI: 10.1016/j.ijbiomac.2023.127202

Abstract

The typical function of Drosha is participating in cleaving pri-miRNA, the initial step of miRNA biogenesis, in the nucleus. Since Drosha has a double-stranded RNA-binding domain and two RNase III domains, when it binds and/or cleaves other RNA species other than pri-miRNA, Drosha is able to induce a variety of novel biological effects. Moreover, by interacting with other protein, Drosha is able to modify the function of other protein complexes. Recently, diverse non-classical functions of Drosha have been demonstrated, such as promoting DNA damage repair, transcriptional activation and inhibition, pre-mRNA splicing regulation, mRNA destabilization, and virus-host interaction. In this review, we describe these newly discovered functions of Drosha in order to present a panoramic picture of the novel biological processes that Drosha is involved in.

Keywords: DROSHA; ncRNAs.

Publication types

Review

MeSH terms

Gene Expression Regulation
MicroRNAs* / genetics
Proteins / metabolism
RNA Processing, Post-Transcriptional
Ribonuclease III* / genetics
Ribonuclease III* / metabolism

Substances

Ribonuclease III
MicroRNAs
Proteins