Progress in the application of the neutrophil-to-lymphocyte ratio in dialysis-related complications

Ren Fail. 2023;45(2):2259996. doi: 10.1080/0886022X.2023.2259996. Epub 2023 Oct 4.

Abstract

The neutrophil-to-lymphocyte ratio (NLR) is a novel predictive biomarker that reflects systemic inflammatory status and is routinely measured in blood tests. Owing to its ease of use and affordability, it is being increasing used as a prognostic indicator of cardiovascular disease, tumors, autoimmune disorders, and kidney disease. In recent years, a number of studies have demonstrated the clinical utility of the NLR in identifying and predicting complications associated with hemodialysis and peritoneal dialysis, including cardiovascular disease and infection. This review aimed to provide a new perspective on the application of the NLR as a valuable tool enabling clinicians to better assess the occurrence and prognosis of complications in patients undergoing dialysis.

Keywords: Neutrophil-to-lymphocyte ratio; complications; disease burden; hemodialysis; peritoneal dialysis.

Publication types

  • Review

MeSH terms

  • Cardiovascular Diseases* / etiology
  • Humans
  • Lymphocytes
  • Neutrophils*
  • Prognosis
  • Renal Dialysis / adverse effects
  • Retrospective Studies

Grants and funding

This research was supported by the Key Project of the Scientific Research Foundation of Chinese Medicine (grant no. 2022ZZ002) and the Zhejiang Province Chinese Medicine Modernization Program (grant no. 2020ZX001). The final version of the manuscript has been read, revised, and approved by all the authors.