Advances in the regulation of adipogenesis and lipid metabolism by exosomal ncRNAs and their role in related metabolic diseases

Cong Liu; Xilin Liu; Hong Li; Zhichen Kang

doi:10.3389/fcell.2023.1173904

Advances in the regulation of adipogenesis and lipid metabolism by exosomal ncRNAs and their role in related metabolic diseases

Front Cell Dev Biol. 2023 Sep 18:11:1173904. doi: 10.3389/fcell.2023.1173904. eCollection 2023.

Authors

Cong Liu¹, Xilin Liu², Hong Li³, Zhichen Kang⁴

Affiliations

¹ Department of Breast Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.
² Department of Hand and Foot Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.
³ Department of Nursing, China-Japan Union Hospital of Jilin University, Changchun, China.
⁴ Department of Rehabilitation, The Second Hospital of Jilin University, Changchun, China.

Abstract

Exosomes are membrane-bound extracellular vesicles released following the fusion of multivesicular bodies (MVBs) with the cell membrane. Exosomes transport diverse molecules, including proteins, lipids, DNA and RNA, and regulate distant intercellular communication. Noncoding RNA (ncRNAs) carried by exosomes regulate cell-cell communication in tissues, including adipose tissue. This review summarizes the action mechanisms of ncRNAs carried by exosomes on adipocyte differentiation and modulation of adipogenesis by exosomal ncRNAs. This study aims to provide valuable insights for developing novel therapeutics.

Keywords: adipogenesis; exosomes; lipid metabolism; ncRNA; obesity-related metabolic diseases.

Publication types

Review

Grants and funding

This work was supported by Science and Technology Department of Jilin Province (YDZJ202201ZYTS532); Health Research Talents Special Project of Jilin Province (2021SCZ31).