Macro, Micro, and Nano-Inspired Bioactive Polymeric Biomaterials in Therapeutic, and Regenerative Orofacial Applications

Gamal A Atia; Hany K Shalaby; Ali B Roomi; Mohamed M Ghobashy; Hager A Attia; Sara Z Mohamed; Ahmed Abdeen; Mohamed Abdo; Liana Fericean; Ioan Bănățean Dunea; Ahmed M Atwa; Tabinda Hasan; Wessam Mady; Afaf Abdelkader; Susan A Ali; Ola A Habotta; Rehab A Azouz; Farag Malhat; Mustafa Shukry; Tarek Foda; Stefania Dinu

doi:10.2147/DDDT.S419361

Macro, Micro, and Nano-Inspired Bioactive Polymeric Biomaterials in Therapeutic, and Regenerative Orofacial Applications

Drug Des Devel Ther. 2023 Sep 27:17:2985-3021. doi: 10.2147/DDDT.S419361. eCollection 2023.

Authors

Gamal A Atia¹, Hany K Shalaby², Ali B Roomi^{3

4}, Mohamed M Ghobashy⁵, Hager A Attia⁶, Sara Z Mohamed⁷, Ahmed Abdeen⁸, Mohamed Abdo^{9

10}, Liana Fericean¹¹, Ioan Bănățean Dunea¹¹, Ahmed M Atwa¹², Tabinda Hasan¹³, Wessam Mady¹⁴, Afaf Abdelkader¹⁵, Susan A Ali¹⁶, Ola A Habotta¹⁷, Rehab A Azouz¹⁸, Farag Malhat¹⁹, Mustafa Shukry²⁰, Tarek Foda²¹, Stefania Dinu²²

Affiliations

¹ Department of Oral Medicine, Periodontology, and Diagnosis, Faculty of Dentistry, Suez Canal University, Ismailia, Egypt.
² Department of Oral Medicine, Periodontology and Oral Diagnosis, Faculty of Dentistry, Suez University, Suez, Egypt.
³ Department of Quality Assurance, University of Thi-Qar, Thi-Qar, Iraq.
⁴ Department of Medical Laboratory, College of Health and Medical Technology, National University of Science and Technology, Thi-Qar, Iraq.
⁵ Radiation Research of Polymer Chemistry Department, National Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Cairo, Egypt.
⁶ Department of Molecular Biology and Chemistry, Faculty of Science, Alexandria University, Alexandria, Egypt.
⁷ Department of Removable Prosthodontics, Faculty of Dentistry, Suez Canal University, Ismailia, Egypt.
⁸ Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, Toukh, Egypt.
⁹ Department of Animal Histology and Anatomy, School of Veterinary Medicine, Badr University in Cairo (BUC), Badr City, Egypt.
¹⁰ Department of Anatomy and Embryology, Faculty of Veterinary Medicine, University of Sadat City, Sadat, Egypt.
¹¹ Department of Biology and Plant Protection, Faculty of Agriculture. University of Life Sciences "King Michael I" from Timișoara, Timișoara, Romania.
¹² Department of Pharmacology and Toxicology, Faculty of Pharmacy, Egyptian Russian University, Cairo, Egypt.
¹³ Department of Basic Sciences, College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
¹⁴ Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia.
¹⁵ Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Benha University, Benha, Egypt.
¹⁶ Department of Radiodiagnosis, Faculty of Medicine, Ain Shams University, Abbassia, 1181, Egypt.
¹⁷ Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt.
¹⁸ Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
¹⁹ Department of Pesticide Residues and Environmental Pollution, Central Agricultural Pesticide Laboratory, Agricultural Research Center, Giza, Egypt.
²⁰ Department of Physiology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt.
²¹ Oral Health Sciences Department, Temple University's Kornberg School of Dentistry, Philadelphia, PA, USA.
²² Department of Pedodontics, Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy Timisoara, Timisoara, 300041, Romania.

Abstract

Introducing dental polymers has accelerated biotechnological research, advancing tissue engineering, biomaterials development, and drug delivery. Polymers have been utilized effectively in dentistry to build dentures and orthodontic equipment and are key components in the composition of numerous restorative materials. Furthermore, dental polymers have the potential to be employed for medication administration and tissue regeneration. To analyze the influence of polymer-based investigations on practical medical trials, it is required to evaluate the research undertaken in this sector. The present review aims to gather evidence on polymer applications in dental, oral, and maxillofacial reconstruction.

Keywords: dental; maxillofacial; oral; polymers; regeneration.

Publication types

Review

MeSH terms

Biocompatible Materials* / pharmacology
Drug Delivery Systems
Polymers
Tissue Engineering*

Substances

Biocompatible Materials
Polymers

Grants and funding

This paper is published from the project 6PFE of the University of Life Sciences “King Mihai I” from Timisoara and Research Institute for Biosecurity and Bioengineering from Timisoara.