Comparison of add-on medications for persistent storage symptoms after α-blocker treatment in BPH patients - a network meta-analysis

BMC Urol. 2023 Oct 3;23(1):154. doi: 10.1186/s12894-023-01327-1.

Abstract

Background: Patients with benign prostatic hyperplasia (BPH) receive α-blockers as first-line therapy to treat lower urinary tract symptoms; however, some individuals still experience residual storage symptoms. Antimuscarinics, β3-agonists, and desmopressin are effective add-on medications. Nevertheless, there is currently no evidence for the appropriate choice of the first add-on medication. This systematic review aimed to investigate the clinical benefits of antimuscarinics, β3-agonists, and desmopressin, in addition to α-blockers, for persistent storage symptoms in BPH patients.

Methods: A comprehensive literature search of randomized controlled trials (RCTs) comparing the efficacy of different add-on medications in BPH patients with persistent storage symptoms despite α-blocker treatment was conducted. Clinical outcomes included the International Prostate Symptom Score (IPSS), IPSS storage subscore, nocturia, micturition, and urgency. A network meta-analysis was performed to estimate the effect size. Surface under cumulative ranking curves (SUCRAs) were used to rank the included treatments for each outcome.

Results: A total of 15 RCTs were identified. Add-on imidafenacin and mirabegron resulted in significant improvement in all outcomes assessed. Other add-on medications such as desmopressin, tolterodine, solifenacin, fesoterodine, and propiverine showed positive benefits for most, but not all, outcomes. Based on the SUCRA rankings, add-on desmopressin was the best-ranked treatment for IPSS and nocturia, and add-on imidafenacin was the best for the IPSS storage subscore and micturition.

Conclusions: BPH patients presenting with persistent storage symptoms despite α-blocker administration are recommended to include additional treatment. Desmopressin and imidafenacin may be considered high-priority add-on treatments because of their superior efficacy compared with other medications.

Keywords: Add-on medications; Alpha-blockers; Benign prostatic hyperplasia; Network meta-analysis; Storage symptoms.

Publication types

  • Systematic Review
  • Meta-Analysis

MeSH terms

  • Adrenergic alpha-Antagonists / therapeutic use
  • Deamino Arginine Vasopressin / therapeutic use
  • Drug Therapy, Combination
  • Humans
  • Lower Urinary Tract Symptoms* / drug therapy
  • Lower Urinary Tract Symptoms* / etiology
  • Male
  • Muscarinic Antagonists / therapeutic use
  • Network Meta-Analysis
  • Nocturia*
  • Prostatic Hyperplasia* / complications
  • Prostatic Hyperplasia* / drug therapy
  • Treatment Outcome

Substances

  • Muscarinic Antagonists
  • Deamino Arginine Vasopressin
  • Adrenergic alpha-Antagonists