Preconditioning Modified-Easix as a Predictor of Prognosis in Allogeneic Hematopoietic Stem Cell Transplant Recipients

Zeynep Arzu Yegin; Emine Merve Savaş; Şeyma Yıldız; Münevver İrem Kök; Meltem Büşra Erdemir; Başak Bostankolu Değirmenci; Zübeyde Nur Özkurt; Münci Yağcı

doi:10.1007/s12288-022-01623-0

Preconditioning Modified-Easix as a Predictor of Prognosis in Allogeneic Hematopoietic Stem Cell Transplant Recipients

Indian J Hematol Blood Transfus. 2023 Oct;39(4):586-597. doi: 10.1007/s12288-022-01623-0. Epub 2023 Jan 4.

Authors

Zeynep Arzu Yegin¹, Emine Merve Savaş¹, Şeyma Yıldız¹, Münevver İrem Kök¹, Meltem Büşra Erdemir², Başak Bostankolu Değirmenci¹, Zübeyde Nur Özkurt¹, Münci Yağcı¹

Affiliations

¹ Department of Hematology, Gazi University Faculty of Medicine, Ankara, Turkey.
² Department of Internal Medicine, Gazi University Faculty of Medicine, Ankara, Turkey.

PMID: 37786821
PMCID: PMC10542067 (available on 2024-10-01)
DOI: 10.1007/s12288-022-01623-0

Abstract

Allogeneic hematopoietic stem cell transplantation (alloHCT) is associated with severe complications, most of which share a common physiopathological background characterized by endothelial dysfunction. A novel risk assessment model, endothelial activation and stress index (EASIX), has been introduced as a predictor of endothelial activation. This retrospective study was performed to evaluate the predictive impact of EASIX/modified-EASIX (mEASIX) on transplant outcome. Medical records of 398 alloHCT recipients [median age: 43(17-71) years; M/F: 243/155] were examined. EASIX/mEASIX were calculated at specific time points before and after transplantation. EASIX/mEASIX were significantly associated with transplant complications including engraftment syndrome, sinusoidal obstruction syndrome, febrile neutropenia and transplant associated thrombotic microangiopathy. The probability of overall survival was significantly higher in low-preconditioning mEASIX (day -7) group (37% vs 25.2%; p = 0.008; HR: 2.057; 95% CI: 1.208-3.504). The probabilities of day30 mortality (2.9% vs 19.4%; p = 0.017; HR: 7.028; 95% CI: 1.418-34.836), day100 mortality (9% vs 33%; p = 0.004; HR: 4.469; 95% CI: 1.619-12.336) and non relapse mortality (44.8% vs 61.4%; p = 0.005; HR: 2.551; 95% CI: 1.318-4.941) were lower in low-preconditioning mEASIX (day -7) group. This retrospective cohort analysis demonstrates the significant impact of EASIX/mEASIX on transplant complications and survival. Prospective analyses are mandatory to assess the predictive role of EASIX/mEASIX in clinical practice.

Keywords: Allogeneic hematopoietic stem cell transplantation; EASIX; Sinusoidal obstruction syndrome; Thrombotic microangiopathy; Vascular endothelial syndrome; mEASIX.

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