American Society of Transplantation and Cellular Therapy Series: #7 - Management of Respiratory Syncytial Virus Infections in Hematopoietic Cell Transplant Recipients

Firas El Chaer; Daniel R Kaul; Janet A Englund; Michael Boeckh; Marjorie V Batista; Susan K Seo; Paul A Carpenter; David Navarro; Hans H Hirsch; Michael G Ison; Genovefa A Papanicolaou; Roy F Chemaly

doi:10.1016/j.jtct.2023.09.018

American Society of Transplantation and Cellular Therapy Series: #7 - Management of Respiratory Syncytial Virus Infections in Hematopoietic Cell Transplant Recipients

Transplant Cell Ther. 2023 Dec;29(12):730-738. doi: 10.1016/j.jtct.2023.09.018. Epub 2023 Sep 30.

Authors

Affiliations

¹ Department of Medicine, Division of Hematology and Oncology, University of Virginia, Charlottesville, Virginia. Electronic address: fe2gh@uvahealth.org.
² Division of Infectious Disease, University of Michigan Medical School, Ann Arbor, Michigan.
³ Department of Pediatrics, University of Washington, Seattle Children's Research Institute, Seattle, Washington.
⁴ Clinical Research and Vaccine and Infectious Disease Divisions, Fred Hutchinson Cancer Center and Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington.
⁵ Department of Infectious Diseases, AC Camargo Cancer Center, Sao Paulo, Brazil.
⁶ Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York.
⁷ Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
⁸ Microbiology Service, Hospital Clínico Universitario, INCLIVA Research Institute, Valencia, and Department of Microbiology, School of Medicine, University of Valencia, Valencia & Centro de Investigación Biomédica en Red de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain.
⁹ Clinical Virology Laboratory, Laboratory Medicine, University Hospital Basel, Basel, Switzerland; Infectious Diseases & Hospital Epidemiology, University Hospital Basel, Basel, Switzerland; Transplantation & Clinical Virology, Department of Biomedicine, University of Basel, Basel, Switzerland.
¹⁰ Respiratory Disease Branch, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland.
¹¹ Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas.

PMID: 37783338
DOI: 10.1016/j.jtct.2023.09.018

Abstract

The Practice Guidelines Committee of the American Society of Transplantation and Cellular Therapy (ASTCT) partnered with its Transplant Infectious Disease Special Interest Group (TID-SIG) to update the 2009 compendium-style infectious disease guidelines for hematopoietic cell transplantation (HCT). A new approach was adopted to better serve clinical providers by publishing each standalone topic in the infectious disease series in a concise format of frequently asked questions (FAQ), tables, and figures. Experts in HCT and infectious diseases identified FAQs and then provided answers based on the strength of the recommendation and the level of supporting evidence. In the seventh guideline in the series, we focus on the respiratory syncytial virus (RSV) with FAQs addressing epidemiology, clinical diagnosis, prophylaxis, and treatment. Special consideration was given to RSV in pediatric, cord blood, haploidentical, and T cell-depleted HCT and chimeric antigen receptor T cell therapy recipients, as well as to identify future research directions.

Keywords: Guidelines; Hematopoietic cell transplantation; Respiratory syncytial virus.

Publication types

Practice Guideline

MeSH terms

Child
Communicable Diseases*
Hematopoietic Stem Cell Transplantation* / adverse effects
Humans
Respiratory Syncytial Virus Infections* / epidemiology
Respiratory Syncytial Virus Infections* / therapy
Respiratory Syncytial Virus, Human*
Transplant Recipients
United States