Genetical and epigenetical profiling identifies two subgroups of pineal parenchymal tumors of intermediate differentiation (PPTID) with distinct molecular, histological and clinical characteristics

Ramin Rahmanzade; Elke Pfaff; Rouzbeh Banan; Philipp Sievers; Abigail K Suwala; Felix Hinz; Henri Bogumil; Asan Cherkezov; Aras Fuat Kaan; Daniel Schrimpf; Dennis Friedel; Kirsten Göbel; Felix Keller; Xavier Saenz-Sardà; Alexander Lossos; Martin Sill; Olaf Witt; Oliver W Sakowitz; Andrey Korshunov; David E Reuss; Nima Etminan; Andreas Unterberg; Miriam Ratliff; Christel Herold-Mende; Wolfgang Wick; Stefan M Pfister; Andreas von Deimling; David T W Jones; Felix Sahm

doi:10.1007/s00401-023-02638-1

Genetical and epigenetical profiling identifies two subgroups of pineal parenchymal tumors of intermediate differentiation (PPTID) with distinct molecular, histological and clinical characteristics

Acta Neuropathol. 2023 Dec;146(6):853-856. doi: 10.1007/s00401-023-02638-1. Epub 2023 Sep 30.

Authors

Ramin Rahmanzade^{1

2}, Elke Pfaff^{3

4

5}, Rouzbeh Banan^{1

2}, Philipp Sievers^{1

2}, Abigail K Suwala^{1

2}, Felix Hinz^{1

2}, Henri Bogumil^{1

2}, Asan Cherkezov^{1

2}, Aras Fuat Kaan^{1

2}, Daniel Schrimpf^{1

2}, Dennis Friedel^{1

2}, Kirsten Göbel^{1

2}, Felix Keller^{1

2}, Xavier Saenz-Sardà⁶, Alexander Lossos⁷, Martin Sill^{3

4}, Olaf Witt^{3

4

8}, Oliver W Sakowitz⁹, Andrey Korshunov^{1

2

3}, David E Reuss^{1

2}, Nima Etminan¹⁰, Andreas Unterberg¹¹, Miriam Ratliff^{10

12}, Christel Herold-Mende¹³, Wolfgang Wick^{14

15}, Stefan M Pfister^{3

4}, Andreas von Deimling^{1

2}, David T W Jones^{3

5}, Felix Sahm^{16

17

18}

Affiliations

¹ Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
² Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
³ Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
⁴ Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, University Hospital Heidelberg, Heidelberg, Germany.
⁵ Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁶ Division of Pathology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
⁷ Departments of Oncology and Neurology, Leslie and Michael Gaffin Center for Neuro-Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
⁸ Clinical Cooperation Unit Pediatric Oncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁹ Neurosurgery Center Ludwigsburg-Heilbronn, RKH Klinikum Ludwigsburg, Ludwigsburg, Germany.
¹⁰ Department of Neurosurgery, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany.
¹¹ Department of Neurosurgery, University Hospital of Heidelberg, Heidelberg, Germany.
¹² Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
¹³ Division of Experimental Neurosurgery, Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany.
¹⁴ Clinical Cooperation Unit Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
¹⁵ Department of Neurology and Neurooncology Program, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany.
¹⁶ Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany. Felix.sahm@med.uni-heidelberg.de.
¹⁷ Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany. Felix.sahm@med.uni-heidelberg.de.
¹⁸ Clinical Cooperation Unit Neuropathology (B300), German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 224, 69120, Heidelberg, Germany. Felix.sahm@med.uni-heidelberg.de.

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Brain Neoplasms* / genetics
Brain Neoplasms* / pathology
Humans
Pineal Gland* / pathology
Pinealoma* / genetics
Pinealoma* / pathology