Protein Nanocarriers Capable of Encapsulating Both Hydrophobic and Hydrophilic Drugs

Jooyong Shin; Blair D Cole; Moosavizadeh Seyedmohammad; Sung In Lim; Yeongseon Jang

doi:10.1007/978-1-0716-3469-1_10

Protein Nanocarriers Capable of Encapsulating Both Hydrophobic and Hydrophilic Drugs

Methods Mol Biol. 2024:2720:143-150. doi: 10.1007/978-1-0716-3469-1_10.

Authors

Jooyong Shin¹, Blair D Cole¹, Moosavizadeh Seyedmohammad², Sung In Lim², Yeongseon Jang³

Affiliations

¹ Department of Chemical Engineering, University of Florida, Gainesville, FL, USA.
² Department of Chemical Engineering, Pukyong National University, Busan, Republic of Korea.
³ Department of Chemical Engineering, University of Florida, Gainesville, FL, USA. y.jang@ufl.edu.

PMID: 37775663
DOI: 10.1007/978-1-0716-3469-1_10

Abstract

Protein nanoparticles are promising targeted drug delivery carriers due to their low toxicity, biodegradability, and abundance of proteins in natural sources. Also, protein nanoparticles enable surface modification with other functional proteins or carbohydrate ligands, which improves the efficacy of targeted drug delivery. Nonetheless, a persistent challenge remains to make versatile protein nanoparticles that deliver diverse types of drugs in a wide range of water solubility. Herein, we describe the methods to fabricate nanoparticles made from bovine serum albumin (BSA) that allow for the encapsulation of both hydrophilic and hydrophobic drug molecules, doxorubicin and bilirubin, respectively.

Keywords: Bilirubin; Bovine serum albumin; Doxorubicin; Drug delivery; Protein nanoparticle(s); Therapeutic particle(s).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Doxorubicin / chemistry
Drug Carriers / chemistry
Drug Delivery Systems* / methods
Nanoparticles* / chemistry
Particle Size
Serum Albumin, Bovine / chemistry
Solubility

Substances

Drug Carriers
Doxorubicin
Serum Albumin, Bovine