A case of early-onset periodontitis with vitamin D deficiency: A case report and literature review

Medicine (Baltimore). 2023 Sep 29;102(39):e35321. doi: 10.1097/MD.0000000000035321.

Abstract

Rationale: Periodontitis is an inflammatory disease with multifactorial etiology. Vitamin D, a fat-soluble vitamin, has protective effects on inflammatory response in various systemic conditions. The clinical features of vitamin D deficiency include growth failure, hypotonia, pathologic fractures, rachitic rosary, tetany and so on. Here we present a case of 12-year-old girl affected by early-onset periodontitis accompanied with vitamin D deficiency.

Patient concerns: A 12-year-old girl with gingival redness, bleeding associated with tooth brushing, and mandibular anterior teeth movement, with difficulty in mastication for the past 2 months. There is no relevant family history or special systemic disease history. The serological microelement test showed vitamin D levels were significantly lower than normal range. Immunological test showed abnormal CD4+/CD8+(CD3+CD4+/CD3+CD8+) ratio as well.

Diagnoses: Based on the clinical and serological findings, this patient was ultimately diagnosed with early-onset periodontitis accompanied with vitamin D deficiency.

Interventions: The main treatments for this patient were 3-fold: periodontal therapy, vitamin D supplement and oral hygiene instructions.

Outcomes: Following 1-year therapy, periodontal conditions recovered and became stable. And serological vitamin D levels returned to normal range.

Lessons: The case of interest serves as an important reminder to clinicians, that the early-onset periodontitis may be associated with micronutrients abnormalities, and early-diagnosis and treatment could avoid the body heathy disorders.

Publication types

  • Review
  • Case Reports

MeSH terms

  • Aggressive Periodontitis*
  • Child
  • Dietary Supplements
  • Female
  • Humans
  • Vitamin D / therapeutic use
  • Vitamin D Deficiency* / complications
  • Vitamin D Deficiency* / drug therapy
  • Vitamins / therapeutic use

Substances

  • Vitamin D
  • Vitamins