A Common Infection in a Highly Atypical Patient: Hematochezia From a Cytomegalovirus Colonic Ulcer in a Young and Healthy Immunocompetent Patient

Nouf Turki; Jacob Newman; Leen Raddaoui; Taylor Brewer; Bedoor Alabbas; Sarah Turki; Mamoun Younes; Marie L Borum; Samuel A Schueler

doi:10.7759/cureus.44274

A Common Infection in a Highly Atypical Patient: Hematochezia From a Cytomegalovirus Colonic Ulcer in a Young and Healthy Immunocompetent Patient

Cureus. 2023 Aug 28;15(8):e44274. doi: 10.7759/cureus.44274. eCollection 2023 Aug.

Authors

Nouf Turki^{1

2}, Jacob Newman³, Leen Raddaoui⁴, Taylor Brewer⁵, Bedoor Alabbas⁶, Sarah Turki⁵, Mamoun Younes⁷, Marie L Borum⁴, Samuel A Schueler¹

Affiliations

¹ Gastroenterology and Hepatology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
² Gastroenterology and Hepatology, King Abdulaziz University Hospital, Jeddah, SAU.
³ Internal Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
⁴ Division of Gastroenterology and Liver Diseases, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
⁵ Internal Medicine, George Washington University, Washington, DC, USA.
⁶ Gastroenterology and Hepatology, Sinai Hospital of Baltimore, Baltimore, USA.
⁷ Pathology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.

Abstract

Gastrointestinal (GI) cytomegalovirus (CMV) infections are far more common in immunocompromised as opposed to immunocompetent patients. Immunocompetent patients who develop GI tract CMV infections are typically older with medical comorbidities. As such, descriptions of GI CMV infections in younger immunocompetent patients are lacking. Here, we present a case of a GI CMV infection in a young and healthy immunocompetent patient. A 41-year-old male with hyperlipidemia and hypothyroidism presented with painless, intermittent hematochezia. He denied changes in bowel habits or appetite, abdominal pain, fevers, chills, fatigue, or weight loss. His history was pertinent for insertive and receptive intercourse with one male partner. Medications were emtricitabine/tenofovir for pre-exposure prophylaxis, levothyroxine, and atorvastatin. A colonoscopy revealed a cecal ulcer surrounded by nodular-appearing mucosa that felt firm and friable when biopsied. The remaining colon and terminal ileum were normal. There was no diverticulosis or hemorrhoids. Pathology was positive for CMV. A subsequent serological evaluation revealed a normal complete blood count and comprehensive metabolic panel. Tests for human immunodeficiency virus, syphilis, viral hepatitis, chlamydia, and gonorrhea were negative. He was treated with valganciclovir 900 mg twice daily for 21 days. A subsequent test for CMV deoxyribonucleic acid polymerase chain was negative. Hematochezia resolved. A repeat colonoscopy revealed normal mucosa in the cecum. GI CMV infections in immunocompetent patients are rare and typically occur in older patients with medical comorbidities. Further, such case reports are needed to inform clinicians about risk factors and the presentation of GI CMV infections in young healthy immunocompetent patients.

Keywords: colon ulcer; cytomegalovirus (cmv); cytomegalovirus colitis; hematochezia; immunocompetent adult.

Publication types

Case Reports