Understanding cervical cancer at single-cell resolution

Shengqin Yue; Qian Wang; Jiajun Zhang; Qinyong Hu; Chao Liu

doi:10.1016/j.canlet.2023.216408

Understanding cervical cancer at single-cell resolution

Cancer Lett. 2023 Nov 1:576:216408. doi: 10.1016/j.canlet.2023.216408. Epub 2023 Sep 26.

Authors

Shengqin Yue¹, Qian Wang¹, Jiajun Zhang¹, Qinyong Hu², Chao Liu³

Affiliations

¹ Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
² Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, 430060, China. Electronic address: rm001223@whu.edu.cn.
³ Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, 430060, China. Electronic address: charles.liu@whu.edu.cn.

PMID: 37769795
DOI: 10.1016/j.canlet.2023.216408

Abstract

Cervical cancer is now the fourth most prevalent malignancy in women worldwide, representing a tremendous burden of cancer. The heterogeneity of complex tumor ecosystem impacts tumorigenesis, malignant progression, and response to treatment; thus, a thorough understanding of the tumor ecosystem is vital for enhancing the prognosis of patients with cervical cancer. The rapid development and widespread use of single-cell sequencing have generated a new paradigm of cancer research, providing a comprehensive and in-depth understanding of cancers. In this review, we give an overview of the recent advances made by leveraging single-cell sequencing studies in the dissection of cervical cancer ecosystem heterogeneity. We highlight the evolution of the cervical cancer ecosystem during tumor initiation, progression, and treatment. High-resolution dissection of cervical cancer at the single-cell level has the potential to drive the development of targeted therapies and enable the realization of personalized medicine.

Keywords: Cancer ecosystem; Cervical cancer; Heterogeneity; Immunotherapy; Single-cell sequencing.

Publication types

Review