A self-powered photoelectrochemical biosensing platform for H-FABP monitoring mediated by CsPbBr3@COF-V

Dongquan Leng; Xiang Ren; Lei Liu; Daopeng Zhang; Nuo Zhang; Huangxian Ju; Qin Wei

doi:10.1016/j.bios.2023.115710

A self-powered photoelectrochemical biosensing platform for H-FABP monitoring mediated by CsPbBr₃@COF-V

Biosens Bioelectron. 2023 Dec 1:241:115710. doi: 10.1016/j.bios.2023.115710. Epub 2023 Sep 23.

Authors

Dongquan Leng¹, Xiang Ren¹, Lei Liu¹, Daopeng Zhang², Nuo Zhang³, Huangxian Ju⁴, Qin Wei⁵

Affiliations

¹ Collaborative Innovation Center for Green Chemical Manufacturing and Accurate Detection, Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, PR China.
² School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo, 255049, PR China.
³ Collaborative Innovation Center for Green Chemical Manufacturing and Accurate Detection, Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, PR China; School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo, 255049, PR China. Electronic address: chm_zhangn@ujn.edu.cn.
⁴ Collaborative Innovation Center for Green Chemical Manufacturing and Accurate Detection, Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, PR China; State Key Laboratory of Analytical Chemistry for Life Science, Department of Chemistry, Nanjing University, Nanjing, 210023, PR China.
⁵ Collaborative Innovation Center for Green Chemical Manufacturing and Accurate Detection, Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, PR China; Department of Chemistry, Sungkyunkwan University, Suwon, 16419, Republic of Korea. Electronic address: sdjndxwq@163.com.

PMID: 37769486
DOI: 10.1016/j.bios.2023.115710

Abstract

Advanced bioelectronic detection based on the integration of modern optical electronics and biological systems has a broad prospect. The strategy of cathode signal amplification in self-powered photoelectrochemical (PEC) immunosensors with excellent performance is rarely reported in the field of immune analysis. Herein, the work demonstrates a self-powered PEC biosensor formed with BiOI photocathode and WO₃/SnS₂/ZnS photoanode, and CsPbBr₃@COF-V was used as the photocathode signal quenching source for the quantitative monitoring of heart fatty acid binding protein (H-FABP). The high efficiency and stable self-powered biosensor formed not only provides continuous and powerful photocurrent response for bioanalysis through reasonable stepped band structure, but also effectively eliminates the interference of reducing substances. The quenching source CsPbBr₃@COF-V greatly affects the photocurrent response due to steric hindrance, weak conductivity, competition with the substrate for dissolved oxygen and excitation light source. And the intervention of this key factor achieves multiple signal amplification effect and opens up an innovative vision for self-powered PEC immunosensor. Taking H-FABP as a representative analyte, the proposed signal amplification self-powered photoelectrochemical presents a broad linear range from 0.0005 to 150 ng/mL with the detection limit of 0.19 pg/mL.

Keywords: CsPbBr(3)@COF–V; H-FABP; Immunosensors; Photoelectrochemical; Self-powered equipment.