Transfer RNAs: A treasure trove that keeps on giving

Venkat Gopalan; Karin Musier-Forsyth

doi:10.1016/j.jbc.2023.105170

Transfer RNAs: A treasure trove that keeps on giving

J Biol Chem. 2023 Oct;299(10):105170. doi: 10.1016/j.jbc.2023.105170. Epub 2023 Sep 27.

Authors

Venkat Gopalan¹, Karin Musier-Forsyth²

Affiliations

¹ Department of Chemistry and Biochemistry, Center for RNA Biology, The Ohio State University, Columbus, Ohio, USA. Electronic address: gopalan.5@osu.edu.
² Department of Chemistry and Biochemistry, Center for RNA Biology, The Ohio State University, Columbus, Ohio, USA. Electronic address: musier-forsyth.1@osu.edu.

Abstract

Transfer RNAs are the adaptors in protein synthesis that provide the key link between the nucleic acid-based genetic blueprint and proteins. While the central role of tRNAs in protein synthesis has been known for over 60 years, recent discoveries of their many non-canonical functions and therapeutic potential have heightened interest in tRNAs. In this thematic series, we highlight some of the developments presented at the recent biennial "International tRNA Workshop". The topics chosen reflect advances that were enabled by the latest technological breakthroughs in structure determination and small RNA sequencing and emphasize the prospects and challenges of tRNA-based medicines to treat human diseases.

MeSH terms

Animals
Base Sequence
Humans
Protein Biosynthesis*
RNA, Transfer* / chemistry
RNA, Transfer* / genetics
RNA, Transfer* / metabolism

Substances

RNA, Transfer

Grants and funding

R35 GM141880/GM/NIGMS NIH HHS/United States