The Use of Historical Controls in Clinical Trials

JAMA. 2023 Oct 17;330(15):1484-1485. doi: 10.1001/jama.2023.16182.
No abstract available

Plain language summary

This JAMA Guide to Statistics and Methods explains the use of historical controls—persons who had received a specific control treatment in a previous study—when randomizing participants to that control treatment in a subsequent trial may not be practical or ethical.

Publication types

  • Comment

MeSH terms

  • Clinical Trials as Topic*
  • Control Groups*
  • Research Design*
  • Sample Size