Single cell RNA sequencing sheds light on infiltrating T cells in idiopathic inflammatory myopathies

EMBO Mol Med. 2023 Oct 11;15(10):e18190. doi: 10.15252/emmm.202318190. Epub 2023 Sep 28.

Abstract

Idiopathic inflammatory myopathies (IIM), also referred to as "myositis," are a group of heterogeneous autoimmune disorders characterised by muscle weakness, atrophy and progressive reduced mobility (Lundberg et al, 2021). IIM represent a significant health burden in adult populations, affecting individuals at a mean age of 50 with an estimated prevalence of 2.9-34 per 100,000 (Dobloug et al, 2015; Svensson et al, 2017). IIM encompass several subtypes including dermatomyositis, immune-mediated necrotising myopathy, inclusion-body myositis, antisynthetase syndrome and polymyositis, which are characterised by specific clinical features, histopathological findings and autoantibody status (Pinal-Fernandez et al, 2020).

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Adult
  • Autoimmune Diseases*
  • Dermatomyositis* / pathology
  • Humans
  • Middle Aged
  • Myositis* / pathology
  • Myositis, Inclusion Body* / pathology
  • Sequence Analysis, RNA
  • T-Lymphocytes