Investigations on Na+, K+-ATPase energy consumption in ion flow of hydrophilic pores by THz unipolar stimulation

Wenfei Bo; Rong Che; Qiang Liu; Xiaobo Zhang; Yintao Hou; Yubin Gong

doi:10.1016/j.isci.2023.107849

Investigations on Na+, K+-ATPase energy consumption in ion flow of hydrophilic pores by THz unipolar stimulation

iScience. 2023 Sep 7;26(10):107849. doi: 10.1016/j.isci.2023.107849. eCollection 2023 Oct 20.

Authors

Wenfei Bo¹, Rong Che¹, Qiang Liu¹, Xiaobo Zhang¹, Yintao Hou¹, Yubin Gong²

Affiliations

¹ College of Information and Communication, National University of Defense Technology, Wuhan 430000, China.
² School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu 610054, China.

Abstract

Terahertz science and technology has recently shown new application prospects in artificial intelligence. It is found that terahertz unipolar stimulation can activate cell membrane hydrophilic pores. However, the behaviors of Na+, K+-ATPase and energy consumption during this period remain unknown. This paper investigates these behaviors by Na+, K+-ATPase and electroporation models, based on the interaction theory between terahertz fields and ions at the cellular level. The effective diameters of life ions are considered in the aqueous solution. From results, Na+, K+-ATPases can be activated and stay for a while before close after the stimulation. Their life ion flows are far lower than the flows via the pores. And their power dissipation is as low as 10^-11 W in both rat neostriatal neurons and guinea pig ventricular myocytes. The results keep tenable in 0.1-1.2 THz. These lay the basis for investigations of information communication mechanisms in cells under terahertz stimulation.

Keywords: Cell biology; Cellular neuroscience; Cellular physiology.