Chitosan-Based Self-Healing Hydrogel: From Fabrication to Biomedical Application

Siyu Pan; Chongyu Zhu; Yuwei Wu; Lei Tao

doi:10.3390/polym15183768

Chitosan-Based Self-Healing Hydrogel: From Fabrication to Biomedical Application

Polymers (Basel). 2023 Sep 14;15(18):3768. doi: 10.3390/polym15183768.

Authors

Siyu Pan¹, Chongyu Zhu², Yuwei Wu³, Lei Tao¹

Affiliations

¹ The Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China.
² Key Laboratory of Science and Technology of Eco-Textile, Ministry of Education, College of Chemistry and Chemical Engineering, Donghua University, Shanghai 201620, China.
³ The Second Dental Center, Peking University School and Hospital of Stomatology, Beijing 100101, China.

Abstract

Biocompatible self-healing hydrogels are new-generation smart soft materials that hold great promise in biomedical fields. Chitosan-based self-healing hydrogels, mainly prepared via dynamic imine bonds, have attracted broad attention due to their mild preparation conditions, excellent biocompatibility, and self-recovery ability under a physiological environment. In this review, we present a comprehensive overview of the design and fabrication of chitosan-based self-healing hydrogels, and summarize their biomedical applications in tissue regeneration, customized drug delivery, smart biosensors, and three/four dimensional (3D/4D) printing. Finally, we will discuss the challenges and future perspectives for the development of chitosan-based self-healing hydrogels in the biomedical field.

Keywords: chitosan; customized drug delivery; fabrication; hydrogel; self-healing; smart biosensors; three/four dimensional (3D/4D) printing; tissue engineering.

Publication types

Review

Grants and funding

This research was funded by the National Science Foundation of China (no. 21971141, 81300851) and the Dushi special project of Tsinghua University (2023Z11DSZ001).