Aggressive Variant of Hepatic Epstein-Barr Virus-Associated Inflammatory Pseudotumor-like Follicular Dendritic Cell Sarcoma with PD-L1 and SSTR2a Expression

Madhur Pardasani; Muthukumarassamy Rajakannu; Mukul Vij; Rajesh Rajalingam; Mohamed Rela

doi:10.3390/diagnostics13182916

Aggressive Variant of Hepatic Epstein-Barr Virus-Associated Inflammatory Pseudotumor-like Follicular Dendritic Cell Sarcoma with PD-L1 and SSTR2a Expression

Diagnostics (Basel). 2023 Sep 12;13(18):2916. doi: 10.3390/diagnostics13182916.

Authors

Madhur Pardasani¹, Muthukumarassamy Rajakannu¹, Mukul Vij¹, Rajesh Rajalingam¹, Mohamed Rela¹

Affiliation

¹ Rela Institute & Medical Centre, Chennai 6000044, India.

Abstract

An aggressive Epstein-Barr virus (EBV)-associated inflammatory pseudotumor-like follicular dendritic cell (IPT-like FDC) sarcoma is reported in an adult female. The patient developed multifocal recurrence and passed away 13 months after the initial surgical resection. A bright field microscopic examination of the tumor demonstrated a classical growth pattern and the diffuse expression of Programmed death ligand 1 (PD-L1) and somatostatin receptor 2a (SSTR2a).

Keywords: Epstein–Barr virus; inflammatory pseudotumor-like follicular dendritic cell sarcoma; pathology; programmed death ligand 1; somatostatin receptor 2a.

Grants and funding

This research received no external funding.