A novel aromatic compound from the fungus Synnemellisia sp. FKR-0921

Arisu Tahara; Kazuki Tani; Miyu Wakatsuki; Toshiyuki Tokiwa; Mayuka Higo; Kenichi Nonaka; Tomoyasu Hirose; Rei Hokari; Aki Ishiyama; Masato Iwatsuki; Yoshihiro Watanabe; Masako Honsho; Yukihiro Asami; Hidehito Matsui; Toshiaki Sunazuka; Hideaki Hanaki; Toshiaki Teruya; Takahiro Ishii

doi:10.1038/s41429-023-00657-4

A novel aromatic compound from the fungus Synnemellisia sp. FKR-0921

J Antibiot (Tokyo). 2023 Dec;76(12):706-710. doi: 10.1038/s41429-023-00657-4. Epub 2023 Sep 27.

Authors

Arisu Tahara¹, Kazuki Tani¹, Miyu Wakatsuki¹, Toshiyuki Tokiwa², Mayuka Higo², Kenichi Nonaka², Tomoyasu Hirose², Rei Hokari², Aki Ishiyama², Masato Iwatsuki², Yoshihiro Watanabe², Masako Honsho², Yukihiro Asami², Hidehito Matsui², Toshiaki Sunazuka², Hideaki Hanaki², Toshiaki Teruya³, Takahiro Ishii⁴

Affiliations

¹ Department of Biosciences and Biotechnology, Faculty of Agriculture, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa, 903-0213, Japan.
² Ōmura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
³ Faculty of Education, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa, 903-0213, Japan.
⁴ Department of Biosciences and Biotechnology, Faculty of Agriculture, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa, 903-0213, Japan. ishiit@agr.u-ryukyu.ac.jp.

PMID: 37758818
DOI: 10.1038/s41429-023-00657-4

Abstract

The filamentous fungus Synnemellisia sp. strain FKR-0921 was obtained from soil collected on Kume Island, Okinawa. The MeOH extract of FKR-0921 cultured on a solid rice medium yielded a new aromatic compound, synnemellisitriol A (1). The structure, including the absolute configuration, was elucidated by spectroscopic analysis (FT-IR, NMR, and HR-ESI-MS), and the absolute configuration at C-9 of 1 was determined using the modified Mosher's method. Additionally, 1 was evaluated for its biological activities, including metallo-β-lactamase inhibitory activity, type III secretion system inhibitory activity, antimicrobial activity, antimalarial activity, and cytotoxicity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Infective Agents / chemistry
Anti-Infective Agents / pharmacology
Hypocreales* / chemistry
Magnetic Resonance Spectroscopy
Molecular Structure
Phenols* / chemistry
Phenols* / pharmacology
Spectroscopy, Fourier Transform Infrared
beta-Lactamase Inhibitors / chemistry
beta-Lactamase Inhibitors / pharmacology

Substances

Phenols
beta-Lactamase Inhibitors
Anti-Infective Agents