Effects of a Multi-Component Mycotoxin-Detoxifying Agent on Oxidative Stress, Health and Performance of Sows

Vasileios G Papatsiros; Christos Eliopoulos; Nikolaos Voulgarakis; Dimitrios Arapoglou; Insaf Riahi; Meritxell Sadurní; Georgios I Papakonstantinou

doi:10.3390/toxins15090580

Effects of a Multi-Component Mycotoxin-Detoxifying Agent on Oxidative Stress, Health and Performance of Sows

Toxins (Basel). 2023 Sep 19;15(9):580. doi: 10.3390/toxins15090580.

Authors

Vasileios G Papatsiros¹, Christos Eliopoulos², Nikolaos Voulgarakis¹, Dimitrios Arapoglou², Insaf Riahi³, Meritxell Sadurní³, Georgios I Papakonstantinou¹

Affiliations

¹ Clinic of Medicine, Faculty of Veterinary Medicine, University of Thessaly, 43100 Karditsa, Greece.
² Institute of Technology of Agricultural Products, Hellenic Agricultural Organization-Demeter (HAO-Demeter), 14123 Athens, Greece.
³ BIŌNTE Animal Nutrition, 43204 Reus, Spain.

Abstract

This in vivo study aimed to investigate the effects of a multi-component mycotoxin-detoxifying agent, containing clays (bentonite, sepiolite), phytogenic feed additives (curcumin, silymarin) and postbiotics (yeast cell wall, hydrolyzed yeast) on the antioxidant capacity, health and reproductive performance of pregnant and lactating sows challenged by mycotoxins. Eighty (80) primiparous sows (mean age 366 ± 3 days) per each of the two trial farms were divided into two groups in each farm: a) T1 (control group): 40 sows received the contaminated feed and b) T2 group (experimental group): 40 sows received the contaminated feed plus the mycotoxin-detoxifying agent, one month before farrowing until the end of the lactation period. Thiobarbituric acid reactive substances (TBARS), protein carbonyls (CARBS) and total antioxidant capacity (TAC) were evaluated as biomarkers of oxidative stress. Clinical and reproductive parameters were recorded. Our results indicate that the administration of a multi-component mycotoxin-detoxifying agent's administration in sow feed has beneficial effects on oxidative stress biomarkers and can improve sows' health and performance.

Keywords: CARBS; TAC; TBARS; curcumin; detoxifying agent; mycotoxin; pig; silymarin; sow; yeast.

Publication types

Randomized Controlled Trial, Veterinary
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antioxidants* / pharmacology
Female
Lactation
Mycotoxins* / toxicity
Oxidative Stress
Pregnancy
Saccharomyces cerevisiae
Swine

Substances

Antioxidants
Mycotoxins

Grants and funding

This research was funded by BIŌNTE NUTRITION S.L. (Calle México 33, Polígono Industrial Tecnoparc, 43204 Reus-Tarragona, Spain), through the Research Committee of the University of Thessaly (grant number 7343).