Proportion and number of incident cancer deaths in coronary artery disease

Jin Liu; Shiqun Chen; Yang Zhou; Haozhang Huang; Qiang Li; Yan Liang; Shaohong Dong; Xiaoyu Huang; Liling Chen; Xueyan Zheng; Ruilin Meng; Congzhuo Jia; Jiyan Chen; Ning Tan; Yong Liu

doi:10.1002/cam4.6595

Proportion and number of incident cancer deaths in coronary artery disease

Cancer Med. 2023 Oct;12(19):20140-20149. doi: 10.1002/cam4.6595. Epub 2023 Sep 27.

Authors

Jin Liu^{1

2}, Shiqun Chen^{1

2

3}, Yang Zhou^{1

2}, Haozhang Huang^{1

2

4}, Qiang Li^{1

2}, Yan Liang⁵, Shaohong Dong⁶, Xiaoyu Huang⁷, Liling Chen⁸, Xueyan Zheng⁹, Ruilin Meng⁹, Congzhuo Jia^{1

2}, Jiyan Chen^{1

2

4

10}, Ning Tan^{1

2

4

10}, Yong Liu^{1

2

4

10}

Affiliations

¹ Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Southern Medical University, Guangzhou, China.
² Department of Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
³ Global Health Research Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Science, Guangzhou, China.
⁴ The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.
⁵ Department of Cardiology, Maoming People's Hospital, Maoming, China.
⁶ Department of Cardiology, Shenzhen People's Hospital, Shenzhen, China.
⁷ Department of Cardiology, Yangjiang People's Hospital, Yangjiang, Guangdong, P.R. China.
⁸ Department of Cardiology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian, P.R. China.
⁹ Institute of Control and Prevention for Chronic Non-Infective Disease, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China.
¹⁰ Guangdong Provincial People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.

Abstract

Background: Globally, coronary artery disease (CAD) and cancer are the leading causes of death. Studies focusing on the proportion and spectrum of cancer mortality among CAD patients are lacking. We aim to characterize the proportion and spectrum of cancer-specific mortality among patients with CAD.

Methods: We analyzed 93,797 hospitalized survivors with angiographically documented CAD between 2007 and 2020 (mean age: 62.8 ± 11.1 years, 24.7% female) from Cardiorenal ImprovemeNt II (CIN-II) cohort.

Results: During the median follow-up of 4.8 years (IQR: 2.6-7.5), 13,162 (14.0%) patients died after discharge. A total of 1223/7703 (15.8% of cause-specific death) CAD patients died of cancer. The three most common types of cancer-specific death were lung (36.1%), liver (13.3%), and colorectum cancer (12.8%). Furthermore, male (adjusted HR 2.38, 95% CI: 1.99-2.85) and older (≥60 vs. <60 years, adjusted HR 3.25, 95%CI 2.72-3.88) patients had a significantly increased cancer-specific mortality.

Conclusions: Our data suggest that nearly one-sixth of death is accounted for cancer among CAD patients within a median follow-up of 4.8 years. Lung, liver, and colorectum cancer are top three cancer-specific mortality. Further studies are needed to reduce cancer mortality for CAD patients, especially in older and male ones.

Trail registration: (ClinicalTrials.gov NCT05050877).

Keywords: cancer-specific mortality; cardio-oncology; coronary artery disease; proportion; spectrum.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Coronary Angiography
Coronary Artery Disease* / epidemiology
Female
Humans
Male
Middle Aged
Neoplasms* / epidemiology
Prospective Studies
Risk Factors

Associated data

ClinicalTrials.gov/NCT05050877