Ginsenoside Rg1 attenuates D-galactose-induced neural stem cell senescence via the Sirt1-Nrf2-BDNF pathway

Eur J Neurosci. 2023 Nov;58(9):4084-4101. doi: 10.1111/ejn.16147. Epub 2023 Sep 27.

Abstract

With the ageing of society's population, neurodegenerative diseases have become an important factor affecting the quality of life and mortality in the elderly. Since its physiopathological processes are complex and the authorized medications have recently been shown to have several adverse effects, the development of safe and efficient medications is urgently needed. In this study, we looked at how ginsenoside Rg1 works to postpone neural stem cell ageing and brain ageing, giving it a solid scientific foundation for use as a therapeutic therapy for neurodegenerative diseases.

Keywords: NSCs; ginsenoside Rg1; senescence.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Brain-Derived Neurotrophic Factor / metabolism
  • Galactose / metabolism
  • Galactose / pharmacology
  • Ginsenosides* / metabolism
  • Ginsenosides* / pharmacology
  • Ginsenosides* / therapeutic use
  • Humans
  • NF-E2-Related Factor 2 / metabolism
  • Neural Stem Cells* / metabolism
  • Neurodegenerative Diseases* / metabolism
  • Quality of Life
  • Sirtuin 1 / metabolism

Substances

  • ginsenoside Rg1
  • Galactose
  • Brain-Derived Neurotrophic Factor
  • NF-E2-Related Factor 2
  • Sirtuin 1
  • Ginsenosides