Beneficial effects of a new neuroprotective compound in neuronal cells and MPTP-administered mouse model of Parkinson's disease

Izumi Kato; Yudai Ogawa; Fumika Yakushiji; Jiro Ogura; Masaki Kobayashi; Naoya Shindo; Satoshi Ichikawa; Katsumi Maenaka; Masahiro Sakaitani

doi:10.1039/d3cc03069e

Beneficial effects of a new neuroprotective compound in neuronal cells and MPTP-administered mouse model of Parkinson's disease

Chem Commun (Camb). 2023 Oct 12;59(82):12306-12309. doi: 10.1039/d3cc03069e.

Authors

Izumi Kato^{1

2}, Yudai Ogawa¹, Fumika Yakushiji^{1

3}, Jiro Ogura⁴, Masaki Kobayashi², Naoya Shindo^{1

5}, Satoshi Ichikawa^{1

3}, Katsumi Maenaka^{1

3

5

6

7

8}, Masahiro Sakaitani¹

Affiliations

¹ Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. maenaka@pharm.hokudai.ac.jp.
² Education Research Center for Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. izumi_k@pharm.hokudai.ac.jp.
³ Global Station for Biosurfaces and Drug Discovery, Hokkaido University, Sapporo 060-0812, Japan.
⁴ Department of Pharmacy, Yamagata University Hospital, 2-2-2 Iida-Nishi, Yamagata-shi, Yamagata 990-9585, Japan.
⁵ Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
⁶ Laboratory of Biomolecular Science, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
⁷ Division of Pathogen Structure, International Institute for Zoonosis Control, Hokkaido University, Sapporo 060-0812, Japan.
⁸ Hokkaido University Institute for Vaccine Research & Development, Hokkaido University, Sapporo 060-0812, Japan.

PMID: 37753573
DOI: 10.1039/d3cc03069e

Abstract

A new compound, a derivative of 3,4,5-trimethoxy-N-phenyl benzamide bearing an 8''-methylimidazopyridine moiety, is found to demonstrate neuroprotective effects by preventing cell death caused by oxidative stress. The compound possesses high solubility and metabolic stability, and inhibits MPTP-induced effects in vivo, indicating high potential as a therapeutic drug for Parkinson's disease.