ToxRefDB v2.1: update to curated in vivo study data in the Toxicity Reference Database

Madison Feshuk; Lori Kolaczkowski; Sean Watford; Katie Paul Friedman

doi:10.3389/ftox.2023.1260305

ToxRefDB v2.1: update to curated in vivo study data in the Toxicity Reference Database

Front Toxicol. 2023 Sep 11:5:1260305. doi: 10.3389/ftox.2023.1260305. eCollection 2023.

Authors

Madison Feshuk¹, Lori Kolaczkowski², Sean Watford³, Katie Paul Friedman¹

Affiliations

¹ Center for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, Washington, DC, United States.
² National Student Services Contractor, Oak Ridge Associated Universities, Oak Ridge, TN, United States.
³ Center for Public Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC, United States.

Abstract

The Toxicity Reference Database (ToxRefDB) contains in vivo study data from over 5,900 guideline or guideline-like studies for over 1,100 chemicals. The database includes information regarding study design, chemical treatment, dosing, treatment group parameters, treatment-related (significantly different from control) and critical (adverse) effects, guided by a controlled effect vocabulary, as well as endpoint testing status according to health effects guideline requirements. ToxRefDB v2.1 is an update to address a compilation error found in ToxRefDB v2.0 that resulted in some effects being inadvertently omitted from the database. Though effect data has been recovered, no new studies were added. The recovered data improves the utility of ToxRefDB as a resource for curated legacy in vivo information, which enhances scientific confidence in vitro high-throughput screening of chemicals and supports retrospective and predictive toxicology applications for which outcomes in traditional regulatory toxicology studies serve as reference information.

Keywords: NAMs; curation; database; in vivo; reference; toxicity.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the US EPA.