With the progress of targeted therapy and immunotherapy for lung cancer, the clinical demand for lung biopsy is increasing. An ideal biopsy specimen can be used not only for histopathological diagnosis, but also for biomarker detection. The ideal biopsy specimen should meet two requirements, including more than 60 mm2 of tumor tissue and containing more than 20% of tumor cells. In order to obtain ideal lung cancer biopsy specimens, advanced imaging techniques are needed to help. In this article, we reviewed the requirements for biopsy specimens based on biomarker detection, as well as the current status and research progress of using imaging techniques for preoperative planning and intraoperative real time guidance of lung cancer biopsy. .
【中文题目：影像计划和实时引导肺癌穿刺活检 在生物标志物检测中的进展】 【中文摘要：随着肺癌个体化治疗的进展，临床对肺癌穿刺活检样本的要求越来越高。一个理想的肺癌活检样本不仅可以实现组织病理学诊断，还能够用于生物标志物检测。理想的活检样本需符合至少60 mm2的肿瘤组织和其内的瘤细胞占比在20%以上。要想获取理想的肺癌穿刺活检样本，就需要先进的影像技术予以帮助。本文就基于生物标志物检测对活检样本的要求及影像在肺癌穿刺活检术前计划穿刺路径及术中实时引导穿刺活检的现状和研究进展予以综述。 】 【中文关键词：肺肿瘤；活检；生物标志物检测；影像】.
Keywords: Biomarker detection; Biopsy; Image; Lung neoplasms.