Research progress on drugs for diabetes based on insulin receptor/insulin receptor substrate

Jingqian Su; Lu Tang; Yingsheng Luo; Jingran Xu; Songying Ouyang

doi:10.1016/j.bcp.2023.115830

Research progress on drugs for diabetes based on insulin receptor/insulin receptor substrate

Biochem Pharmacol. 2023 Nov:217:115830. doi: 10.1016/j.bcp.2023.115830. Epub 2023 Sep 23.

Authors

Jingqian Su¹, Lu Tang², Yingsheng Luo², Jingran Xu², Songying Ouyang³

Affiliations

¹ Fujian Key Laboratory of Innate Immune Biology, Biomedical Research Center of South China, College of Life Sciences, Fujian Normal University, Fuzhou 350117, China; Key Laboratory of Microbial Pathogenesis and Interventions of Fujian Province University, College of Life Sciences, Fujian Normal University, Fuzhou 350117, China. Electronic address: sjq027@fjnu.edu.cn.
² Fujian Key Laboratory of Innate Immune Biology, Biomedical Research Center of South China, College of Life Sciences, Fujian Normal University, Fuzhou 350117, China; Key Laboratory of Microbial Pathogenesis and Interventions of Fujian Province University, College of Life Sciences, Fujian Normal University, Fuzhou 350117, China.
³ Fujian Key Laboratory of Innate Immune Biology, Biomedical Research Center of South China, College of Life Sciences, Fujian Normal University, Fuzhou 350117, China; Key Laboratory of Microbial Pathogenesis and Interventions of Fujian Province University, College of Life Sciences, Fujian Normal University, Fuzhou 350117, China; Key Laboratory of OptoElectronic Science and Technology for Medicine of the Ministry of Education, Fujian Normal University, Fuzhou 350117, China. Electronic address: ouyangsy@fjnu.edu.cn.

PMID: 37748666
DOI: 10.1016/j.bcp.2023.115830

Abstract

The number of people with diabetes worldwide is increasing annually, resulting in a serious economic burden. Insulin resistance is a major pathology in the early onset of diabetes mellitus, and therefore, related drug studies have attracted research attention. The insulin receptor/insulin receptor substrate (INSR/IRS) serves as the primary conduit in the insulin signal transduction cascade, and dysregulation of this pathway can lead to insulin resistance. Currently, there exist a plethora of hypoglycemic drugs in the market; however, drugs that specifically target INSR/IRS are comparatively limited. The literature was collected by direct access to the PubMed database, and was searched using the terms "diabetes mellitus; insulin resistance; insulin receptor; insulin receptor substrate; diabetes drug" as the main keywords for literature over the last decade. This article provides a comprehensive analysis of the structure and function of INSR and IRS proteins, as well as the drugs used for the treatment of diabetes. Additionally, it serves as a valuable reference for the advancement of novel therapeutic agents for diabetes management.

Keywords: Diabetes drug; Diabetes mellitus; Insulin receptor; Insulin receptor substrate; Insulin resistance.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Diabetes Mellitus* / drug therapy
Diabetes Mellitus, Type 2* / drug therapy
Humans
Hypoglycemic Agents / pharmacology
Hypoglycemic Agents / therapeutic use
Insulin / metabolism
Insulin Receptor Substrate Proteins / metabolism
Insulin Resistance*
Receptor, Insulin / metabolism

Substances

Receptor, Insulin
Insulin
Hypoglycemic Agents
Insulin Receptor Substrate Proteins