Is endoscopic sinus surgery sufficient to modify the evolution of adult AERD? Aspirin desensitization as a maintenance factor: systematic review

Diego M Conti; Eduardo J Correa; Glenis K Scadding

doi:10.3389/falgy.2023.1250178

Is endoscopic sinus surgery sufficient to modify the evolution of adult AERD? Aspirin desensitization as a maintenance factor: systematic review

Front Allergy. 2023 Sep 8:4:1250178. doi: 10.3389/falgy.2023.1250178. eCollection 2023.

Authors

Diego M Conti¹, Eduardo J Correa², Glenis K Scadding^{3

4}

Affiliations

¹ The European Forum for Research and Education in Allergy and Airway Diseases Scientific Expert Team Members, Brussels, Belgium.
² Otolaryngology Department, Hospital Comarcal de la Línea de La Concepción, Cádiz, Spain.
³ Department of Allergy & Rhinology, Royal National ENT Hospital, London, United Kingdom.
⁴ Division of Immunity and Infection, University College, London, United Kingdom.

Abstract

Introduction: Aspirin desensitization (AD) and aspirin therapy after desensitization (ATAD) are therapeutic interventions for patients with aspirin-exacerbated respiratory disease (AERD). Our aim is to investigate whether its addition to endoscopic sinus surgery (ESS) improves the overall prognosis of the disease.

Methods: A systematic review of the current literature including adult patients with a positive diagnosis of AERD undergoing endoscopic sinus surgery (ESS) in the context or in absence of upper airway comorbidity, prior to AD + ATAD.

Conclusion: This review concludes that the surgical approach is beneficial in AERD, but its effects are short-lived. Surgery should be considered initially with subsequent AD + ATAD in AERD patients, due to the sustained improvement achieved compared to those receiving ESS alone.

Keywords: AERD; ATAD; CRSwNP; ESS; FESS; N-ERD; aspirin desensitization; sinus surgery.

Publication types

Review